30274-05-6 Usage
Acyl chloride derivative
A compound derived from 2,2-dimethyl-3-oxobutyric acid.
Uses
Used in organic synthesis for the preparation of various organic compounds, including pharmaceuticals and agrochemicals.
Physical properties
A colorless to pale yellow liquid with a pungent odor.
Reactivity
Highly reactive, especially towards nucleophiles.
Handling and storage
Must be handled with caution and stored in a cool, dry place away from heat and moisture.
Safety measures
It is important to use appropriate safety measures when working with 2,2-dimethyl-3-oxobutyryl chloride, such as wearing protective gloves and eyewear.
Check Digit Verification of cas no
The CAS Registry Mumber 30274-05-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,2,7 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 30274-05:
(7*3)+(6*0)+(5*2)+(4*7)+(3*4)+(2*0)+(1*5)=76
76 % 10 = 6
So 30274-05-6 is a valid CAS Registry Number.
30274-05-6Relevant academic research and scientific papers
Intramoleclar Nucleophilic Catalysis during Alkaline Hydrolysis of Nonenolizable β-Keto-Esters
Washburn, William N.,Cook, Ewell R.
, p. 5962 - 5964 (2007/10/02)
Kinetic and 18O-labeling studies demonstrate that in the hydrolysis of nonenolizable acetoacetate esters, the carbonyl hydrate acts as a nucleophilic catalyst.A cyclic four-membered lactone is formed and later opens.Structure/reactivity studies showed the rate-determining step to be a function of the pKa of the leaving group and the substituent bound to C3 of the acetoacetate residue.Rate accelerations of 4 to E4 were observed for hydrolyses of the corresponding p-nitrophenyl esters, depending on the substituent at C3.
