302800-07-3Relevant articles and documents
Subtype-selective N-methyl-D-aspartate receptor antagonists: Synthesis and biological evaluation of 1-(heteroarylalkynyl)-4-benzylpiperidines
Wright,Gregory,Kesten,Boxer,Serpa,Meltzer,Wise,Espitia,Konkoy,Whittemore,Woodward
, p. 3408 - 3419 (2007/10/03)
4-[4-(4-Benzylpiperidin-1-yl)but-1-ynyl]phenol (8) and 4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-phenol (9) are potent NR1A/2B receptor antagonists (IC50 values 0.17 and 0.10 μM, respectively). Administered intraperitoneally, they both potentia