302818-50-4Relevant academic research and scientific papers
Reaction of 6-aminouracils with aldehydes in water as both solvent and reactant under FeCl3·6H2O catalysis: Towards 5-alkyl/arylidenebarbituric acids
Kalita, Subarna Jyoti,Mecadon, Hormi,Chandra Deka, Dibakar
, p. 32207 - 32213 (2014/08/18)
5-Alkyl/arylidenebarbituric acids were efficiently synthesized through an FeCl3·6H2O catalyzed domino reaction of 6-aminouracils, water and aldehydes with water serving a dual role as both solvent and reactant, under benign reaction conditions. A study on comparative substrate scope of 6-aminouracil versus barbituric acid showed similar efficacy towards 5-alkyl/arylidenebarbituric acids. The protocol is the first detailed report to prepare regioselectively 5-alkyl/arylidenebarbituric acids starting from 6-aminouracils, which is an alternative and competing strategy to hitherto all known reactions directly employing barbituric acids. the Partner Organisations 2014.
A facile and clean synthesis of pyrimidine derivatives via three-component reaction in aqueous Media
Shi, Daqing,Shi, Jingwen,Rong, Shaofeng
experimental part, p. 791 - 796 (2010/11/02)
A series of 5-benzylidenepyrimidine-2,4,6(1H,3H,5H)-trione and 5,5'-(arylmethylene) bis[6-aminopyrimidine-2,4(1H,3H)-dione] derivatives were synthesized via the three-component reactions of aromatic aldehyde, 6-aminopyrimidine-2,4-dione and Medrum's acid in aqueous media in the presence of triethylbenzylammonium chloride. The structures of the products were affected by substituents of aromatic aldehydes.
