302923-29-1

Upstream product

• 851705-05-0 C₁₁H₁₂N₂O₄ 
• 4403-71-8 (4-aminomethyl)aniline 
• 102423-16-5 allyl 1-benzotriazolyl carbonate 

Downstream Products

• 651311-53-4 4-[4-(allyloxycarbonylamino-methyl)-phenylamino]-2-phenyl-quinoline-8-carboxylic acid methyl ester 
• 651311-56-7 4-[4-(allyloxycarbonylamino-methyl)-phenylamino]-2-(4-nitro-phenyl)-quinoline-8-carboxylic acid methyl ester 
• 851705-06-1 C₂₇H₄₂N₄O₄ 
• 302923-28-0 9-(4'-methylamino-allyloxycarbamate)anilinoacridine-4-carboxylic acid 
• 881744-14-5 methyl 4-(4'-methylaminoallyloxycarbamate)anilino-quinoline-8-carboxylate 
• 302923-30-4 iso-propyl-9-(4'-methylaminoallyl-oxycarbamate)anilinoacridine-4-carboxylate 

Relevant academic research and scientific papers

BIPIPERIDINYL DERIVATIVES USEFUL AS INHIBITORS OF CHEMOKINE RECEPTORS

In its many embodiments, the present invention provides a novel class of bipiperidinyl compounds as inhibitors of the CCR5 receptors, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with CCR5 using such compounds or pharmaceutical compositions. The invention also relates to the use of a combination of a compound of this invention and one or more antiviral or other agents useful in the treatment of Human Immunodeficiency Virus (HIV). The invention further relates to the use of a compound of this invention, alone or in combination with another agent, in the treatment of solid organ transplant rejection, graft v. host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergies or multiple sclerosis.

Solid-phase synthesis of acridine-based threading intercalator peptides

The preparation of a novel acridine-based amino acid is reported. This N-Alloc-protected monomer can be coupled and deprotected under solid-phase peptide synthesis procedures to create acridine-peptide conjugates as potential threading intercalators. A peptide containing this novel amino acid undergoes spectral changes in the presence of duplex DNA and RNA consistent with intercalative binding. (C) 2000 Elsevier Science Ltd.