302923-30-4Relevant academic research and scientific papers
Solid-phase synthesis of acridine-based threading intercalator peptides
Carlson, Coby B.,Beal, Peter A.
, p. 1979 - 1982 (2000)
The preparation of a novel acridine-based amino acid is reported. This N-Alloc-protected monomer can be coupled and deprotected under solid-phase peptide synthesis procedures to create acridine-peptide conjugates as potential threading intercalators. A peptide containing this novel amino acid undergoes spectral changes in the presence of duplex DNA and RNA consistent with intercalative binding. (C) 2000 Elsevier Science Ltd.
