302932-49-6Relevant academic research and scientific papers
Enantioselective N-Acylation of Biginelli Dihydropyrimidines by Oxidative NHC Catalysis
Brandolese, Arianna,Ragno, Daniele,Leonardi, Costanza,Di Carmine, Graziano,Bortolini, Olga,De Risi, Carmela,Massi, Alessandro
, p. 2439 - 2447 (2020/04/30)
The oxidative N-acylation reaction of 3,4-dihydropyrimidin-2-(1H)-ones (DHPMs) with enals and N-heterocyclic carbene (NHC) catalysts is described. The reaction proceeds in the presence of quinone oxidant without additional acyl transfer agents and in the
Reduction of Biginelli compounds by LiAlH4: a rapid access to molecular diversity
Zlatkovi?, Dragan B.,Radulovi?, Niko S.
, p. 115058 - 115067 (2016/12/24)
Herein, the reduction of Biginelli compounds by LiAlH4 was investigated for the first time. The reduction of urea-derived dihydropyrimidinones yielded 80-95% of hydrogenolysis products (4-aryl-5-(m)ethyl-6-methyl-3,4-dihydropyrimidin-2(1H)-ones
Phytic acid: A biogenic organocatalyst for one-pot Biginelli reactions to 3,4-dihydropyrimidin-2(1H)-ones/thiones
Zhang, Qiguo,Wang, Xin,Li, Zhenjiang,Wu, Wenzhuo,Liu, Jingjing,Wu, Hao,Cui, Saide,Guo, Kai
, p. 19710 - 19715 (2014/05/20)
The natural organocatalyst phytic acid catalyzed one-pot Biginelli reactions by coupling β-ketoesters, aldehydes, and (thio)ureas to afford 3,4-dihydropyrimidin-2(1H)-ones/thiones. This phytic acid catalysis featured good to excellent isolated yields, sol
Highly regioselective addition of organozinc reagents to 2-Oxo-1,2-dihydropyrimidine-5-carboxylates activated by BF3· OEt2: Synthesis of 2-Oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates
Singh, Kamaljit,Chopra, Rakesh
, p. 6124 - 6129 (2013/09/24)
The incorporation of alkyl as well as phenyl groups at C-4, a key position of 2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates, responsible for antagonist/agonist switching of the calcium channel blocking activity of these compounds, has been achieved by the addition of organozinc reagents to the corresponding 2-oxo-1,2-dihydropyrimidine-5-carboxylate derivatives catalysed by BF3OEt2. An efficacious diversification of the key C-4 position of 2-oxo-1,2-dihydropyrimidine-5-carboxylates has been achieved through the addition of organozinc reagents.
A convenient one-pot Biginelli reaction catalyzed by Y(OAc)3: An improved protocol for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and their sulfur analogues
Aridoss, Gopalakrishnan,Jeong, Yeon Tae
experimental part, p. 863 - 868 (2010/10/19)
Yttrium(III) acetate hydrate-catalyzed novel synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)one derivatives was achieved through one-pot three-component condensation of diversified aldehydes, β-ketoesters and urea or N-methylurea or thiourea with a molar r
