302969-60-4

Upstream product

• 108-30-5 succinic acid anhydride 
• 265648-28-0 N-(4-amino-2-benzoylphenyl)-2-(4-methylphenyl)acetic acid amide 
• 35675-44-6 4-methylphenylacetyl chloride 
• 1775-95-7 2-amino-5-nitrobenzophenone 
• 265648-27-9 N-(2-benzoyl-4-nitrophenyl)-2-(4-methylphenyl)acetic acid amide 

Relevant academic research and scientific papers

Non-thiol farnesyltransferase inhibitors: The concept of benzophenone- based bisubstrate analogue farnesyltransferase inhibitors

Replacement of the thiol in a benzophenone-based CAAX-peptidomimetic farnesyltransferase inhibitor by a carboxylic acid moiety resulted in a marked drop in inhibitory potency. Transformation of these carboxylic acid derivatives into bisubstrate analogues by addition of a lipophilic alkyl chain, which should be able to occupy considerable portions of the farnesyl binding region in the farnesyltransferase's active site, resulted in a regain of the inhibitory activity. The bisubstrate analogues represent new lead structures for non-thiol farnesyltransferase inhibitors. (C) 2000 Editions scientifiques et medicales Elsevier SAS.