30299-08-2 Usage
Chemical Properties
White Solid
Originator
Lipocrin,Sumitomo,Japan,1981
Uses
Clinofibrate is an antilipemic, used as an anti-atherosclerosis agent.
Manufacturing Process
Into a mixture of 6.0 g of a bishydroxyphenyl derivative, and 44.0 g of methyl
ethyl ketone was added 16.2 g of crushed potassium hydroxide or sodium
hydroxide. Chloroform was added dropwise into the above mixture with
stirring at 20°C to 80°C, and the resultant mixture was heated for 20 hours
under reflux to complete the reaction. Thereafter the reaction mixture was
concentrated to give a residue. Into the residue was added water. After
cooling, the resultant mixture was treated with activated charcoal and
acidified by diluted hydrochloric acid or sulfuric acid to give an oily substance.
The oily substance was extracted by ether and the ether solution was
contacted with aqueous diluted Na2CO3 solution. The separated aqueous layer
was washed with ether, acidified and again extracted with ether. The obtained
ester layer was dried over anhydrous sodium sulfate and concentrated to give
1.0 g of a crude product which was purified by recrystallization or
chromatography, to give crystals MP 143°C to 146°C (decomp.)
Check Digit Verification of cas no
The CAS Registry Mumber 30299-08-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,0,2,9 and 9 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 30299-08:
(7*3)+(6*0)+(5*2)+(4*9)+(3*9)+(2*0)+(1*8)=102
102 % 10 = 2
So 30299-08-2 is a valid CAS Registry Number.
InChI:InChI=1/C28H36O6/c1-5-26(3,24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32)
30299-08-2Relevant articles and documents
Method for preparing high-purity kerley Bette
-
, (2016/10/07)
The invention relates to a preparation method of high-purity clinofibrate, the field of preparation of pharmaceutical compounds. The preparation method comprises the following steps: reacting cyclohexanone and phenol in concentrated hydrochloric acid and glacial acetic acid in a volume ratio of 3:1-7:1 to obtain an intermediate I crude product, decolorizing with a single solvent, and cooling to crystallize to obtain an intermediate I; reacting 2-methylbutyric acid with liquid bromine in phosphorus trichloride, reacting with anhydrous alcohol, extracting, and carrying out vacuum distillation to obtain an intermediate II; reacting the intermediate I and the intermediate II under solventless conditions to obtain an intermediate III; and hydrolyzing the intermediate III and sodium hydroxide, extracting, crystallizing to obtain a clinofibrate crude product; and recrystallizing with an anhydrous solvent to obtain the clinofibrate. The material proportion is adjusted to shorten the production operation period; the invention has the advantages of low energy consumption and low solvent consumption; and the obtained product has the advantages of uniform crystal grains, high purity and low cost.
