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Cyclizine Hydrochloride (200 MG) is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It is a piperazine derivative with anti-emetic activity, acting as an H1-receptor antagonist, a central nervous system depressant, a cholinergic antagonist, and an antiemetic. This off-white solid is used for the prevention and treatment of nausea and vomiting associated with various conditions.
Used in Pharmaceutical Industry:
Cyclizine Hydrochloride (200 MG) is used as an antiemetic for the prophylaxis and treatment of nausea, vomiting, and dizziness associated with motion sickness. It helps alleviate the discomfort and distress caused by motion sickness, making it easier for individuals to travel and engage in activities that involve movement.
Used in Postoperative Care:
Cyclizine Hydrochloride (200 MG) is used as a prophylactic and treatment agent for nausea and vomiting that occur after surgeries. By preventing or relieving these symptoms, it contributes to a smoother recovery process and improved patient comfort during the postoperative period.

303-25-3

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303-25-3 Usage

Originator

Marezine,BurroughsWellcome,US,1953

Manufacturing Process

One-tenth mol (20 g) of benzhydryl chloride was mixed with 0.19 mol (19 g) of N-methylpiperazine and about 10 cc of benzene and the whole was heated on the steam bath four hours. The contents of the flask was partitioned between ether and water, and the ethereal layer was washed with water until the washings were neutral. The base was then extracted from the ethereal layer by N hydrochloric acid and the extract, made acid to Congo red paper, was evaporated under vacuum. 29.5 g of the pure dihydrochloride of Nmethyl-N'-benzhydryl piperazine was recovered from the residue by recrystallization from 95% alcohol melting above 250°C with decomposition. The addition of alkali to an aqueous solution of the dihydrochloride liberated the base which was recovered by recrystallization from petroleum ether melting at 105.5° to 107.5°C.

Therapeutic Function

Antinauseant

Check Digit Verification of cas no

The CAS Registry Mumber 303-25-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,0 and 3 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 303-25:
(5*3)+(4*0)+(3*3)+(2*2)+(1*5)=33
33 % 10 = 3
So 303-25-3 is a valid CAS Registry Number.
InChI:InChI=1/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H

303-25-3 Well-known Company Product Price

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  • Sigma-Aldrich

  • (C3090000)  Cyclizinehydrochloride  (European Pharmacopoeia (EP) Reference Standard)

  • 303-25-3

  • C3090000

  • 1,880.19CNY

  • Detail

  • USP

  • (1154004)  Cyclizinehydrochloride  United States Pharmacopeia (USP) Reference Standard

  • 303-25-3

  • 1154004-200MG

  • 4,662.45CNY

  • Detail

303-25-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name cyclizine hydrochloride

1.2 Other means of identification

Product number -
Other names Cyclizine hydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:303-25-3 SDS

303-25-3Synthetic route

N-benzhydryl-N'-methylpiperazine
82-92-8

N-benzhydryl-N'-methylpiperazine

cyclizine hydrochloride
303-25-3

cyclizine hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In methanol; water at 45 - 55℃; for 2h;90.5%

303-25-3Downstream Products

303-25-3Relevant academic research and scientific papers

AN IMPROVED PROCESS FOR THE PREPARATION OF AN ANTIHISTAMINE AGENT

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Page/Page column 14, (2018/02/03)

The present invention relates to an improved process for the preparation of an antihistamine agent. The present invention particularly relates to an improved process for the preparation of Cyclizine or its salts. The present invention more particularly relates to an improved process for the preparation of Cyclizine hydrochloride. The present invention further relates to commercially feasible process for the preparation of Cyclizine hydrochloride.

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