CAS No.303-25-3,CYCLIZINE HYDROCHLORIDE (200 MG) Suppliers

Products Categories

Pharmaceutical (35)
Others (8)
Organic Chemicals (6)
Materials (1)

Basic Information

Molecular Structure:
CAS No.:	303-25-3
Name:	CYCLIZINE HYDROCHLORIDE (200 MG)

Formula:	C₁₈H₂₃ClN₂
Molecular Weight:	302.847
Synonyms:	Piperazine,1-(diphenylmethyl)-4-methyl-, monohydrochloride (8CI,9CI);Marezine hydrochloride;Marzine;N-Benzhydryl-N'-methylpiperazine monohydrochloride;
EINECS:	206-136-9
Density:	1.0551 (rough estimate)
Melting Point:	258-260 °C
Boiling Point:	363.7 °C at 760 mmHg
Flash Point:	159.1 °C
Appearance:	Off-white solid
Hazard Symbols:	T
Risk Codes:	61-23/24/25-42/43
Safety:	53-22-36/37/39-45
Transport Information:	UN 3249
PSA:	6.48000
LogP:	3.70120

Synthetic route

: 82-92-8
N-benzhydryl-N'-methylpiperazine

: 303-25-3
cyclizine hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In methanol; water at 45 - 55℃; for 2h;	90.5%

Country:
Business Type:
All

Lab/Research institutions

Trading Company

Manufacturers

Other
Certificate:
Manufacturer

Enterprise Authentication

ISO

GMP

FDA

HALAL

Display:default sort
Suppiers of more reward points first

New supplier

Total:48 Page 1 of 2 1 2 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 303-25-3

Specification

The Cyclizine hydrochloride, with the CAS registry number 303-25-3, is also known as 1-(Diphenylmethyl)-4-methylpiperazine monohydrochloride. Its EINECS registry number is 206-136-9. This chemical's molecular formula is C₁₈H₂₃ClN₂ and molecular weight is 302.84162. Its IUPAC name is called 1-benzhydryl-4-methylpiperazine hydrochloride. This chemical's classification codes are Anti-emetic; Drug / Therapeutic Agent; Reproductive Effect.

Physical properties of Cyclizine hydrochloride: (1)ACD/LogP: 2.41; (2)ACD/LogD (pH 5.5): 0.12; (3)ACD/LogD (pH 7.4): 1.82; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 10.29; (6)ACD/KOC (pH 5.5): 2.5; (7)ACD/KOC (pH 7.4): 125.76; (8)#H bond acceptors: 2; (9)#Freely Rotating Bonds: 3; (10)Flash Point: 159.1 °C; (11)Enthalpy of Vaporization: 60.98 kJ/mol; (12)Boiling Point: 363.7 °C at 760 mmHg; (13)Vapour Pressure: 1.77E-05 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=CC=C3.Cl
(2)InChI: InChI=1S/C18H22N2.ClH/c1-19-12-14-20(15-13-19)18(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18H,12-15H2,1H3;1H
(3)InChIKey: UKPBEPCQTDRZSE-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	58mg/kg (58mg/kg)		Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 241, 1975.
mouse	LD50	oral	165mg/kg (165mg/kg)	BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 112, Pg. 297, 1954.
pigeon	LD50	intramuscular	106mg/kg (106mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING	Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 46, Pg. 140, 1957.