3030-19-1

Upstream product

• 2148-56-3 2-chloro-6-aminobenzoic acid 
• 7463-35-6 N-(3-chloro-2-methylphenyl)acetamide 
• 87-60-5 3-chloro-2-methylbenzenamine 
• 125328-77-0 N-acetyl-5-bromo-6-chloroanthranilic acid 
• 125328-80-5 N-(4-bromo-3-chloro-2-methylphenyl)acetamide 
• 627531-47-9 4-amino-2-chloro-3-methylbromobenzene 

Downstream Products

• 1447125-25-8 C₁₅H₁₅BrClNO₄ 
• 125328-84-9 (5-Bromo-4-chloro-indol-3-yl)-β-L-fucopyranoside 
• 153248-52-3 5-bromo-4-chloro-indol-3-yl-(5-acetamido-3,5-dideoxy-α-D-glycero-D-galacto-2-nonulopyranosylonic acid) 
• 7240-90-6 5-bromo-4-chloro-3-indolyl β-D-galactopyranoside 
• 1607828-63-6 (5-bromo-4-chloroindol-3-yl) (β-D-galactopyranosyl)-(1→4)-β-D-glucopyranoside 
• 6388-45-0 5-bromo-6-chloro-N-[(methoxycarbonyl)methyl]anthranilic acid methyl ester 

Relevant academic research and scientific papers

Synthetic method 5- of -4- (-1- I -3-)-(C)-(C)-ethyl-methyl-indol. (by machine translation)

To the method, the 3 - indole chromogenic 5 - substrate is obtained, by hydrolyzing the indole phenol with acetic. anhydride, under an acidic condition with acetic, anhydride to form an indole, chromogenic substrate by hydrolyzing the, indole phenol, with acetic anhydride under an acidic, condition with acetic anhydride under an acidic condition 5 - 5 . (by machine translation)

Synthesis method of 5-bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic acid sodium salt

The invention provides a synthesis method of 5-bromo-4-chloro-3-indolyl-alpha-D-N-acetylneuraminic acid sodium salt. In the prior art, a lot of inflammable and explosive compounds are used, methyl is oxidized through potassium permanganate to form acid, and the potassium permanganate is the explosive compound; triphosgene is used and dangers are easy to occur; sodium hydride is used and the compound is combusted when meeting water, and then is exploded; the requirements on operation are very high. In a process route of the prior art, a lot of waste acids are generated and influences on the environment are relatively great; noble metal including silver and palladium is used in the process so that reaction cost is high, and heavy metal remains in a product and influences on the quality of the product are very great. The invention provides a preparation method which is simple to operate, high in safety, few in side reactions, high in conversion rate, high in yield, small in environment pollution and low in production cost and is suitable for industrial production.

Indoxylic acid esters as convenient intermediates towards indoxyl glycosides

Indoxylic acid methyl and allyl esters with varied halide-substitution patterns were obtained in excellent yields using a scalable route. Phase-transfer glycosylation of these key intermediates was carried out with various glycosyl halides. Subsequent mild silver-mediated decarboxylation followed by Zemplen deacetylation led to indoxyl glycosides in good overall yields. Indoxyl glycosides are well-established and widely used tools for enzyme screening and enzyme-activity monitoring. In the past, their synthesis has been difficult, so this new approach has led to a variety of useful structures. Indoxyl glycosides with varied halide-substitution patterns were synthesized using indoxylic acid esters as key intermediates. Glycosylation under phase-transfer conditions, ester cleavage, and mild decarboxylation led to the indoxyl glycosides in good yields. This approach enables access to a number of different indoxyl compounds. Copyright

Novel efficient routes to indoxyl glycosides for monitoring glycosidase activities

A new efficient synthesis for broad access to indoxyl glycosides was developed. Indoxylic acid allyl ester linked to a sugar structure served as the key intermediate in this route. Selective ester cleavage and mild decarboxylation led to the corresponding indoxyl glycosides in good yields. This synthesis was applied for preparation of indoxyl glycosides of fucose, sialic acid, and 6′-sialyl lactose.