3030-97-5Relevant academic research and scientific papers
Synthesis and structural studies of mono- and dinuclear Cu(II) complexes with an ONO donor Schiff base ligand: Self-assembly and sulfato-bridged
Vafazadeh, Rasoul,Esteghamat-Panah, Roya,Willis, Anthony C.,Hill, Anthony F.
, p. 51 - 57 (2012)
Five Cu(II) complexes, [CuL(NO3)] (1), [CuLBr][CuLCH 3OH]2Br2 (2), [CuLN3] (3), [CuL(ClO4)]2 (4) and [H2OLCu(μ-SO 4)CuLH2O] (5), where L is the s
In-house chemical library repurposing: A case example for Pseudomonas aeruginosa antibiofilm activity and quorum sensing inhibition
Ravithej Singh,Tripathi, Vikash C.,Raj, Sneha,Kumar, Anoop,Gupta, Sampa,Horam, Soyar,Upadhyay, Akanksha,Kushwaha, Pragati,Arockiaraj, Jesu,Sashidhara, Koneni V.,Pasupuleti, Mukesh
, p. 383 - 390 (2018)
(Table presented.). Drug repurposing has become a recent trend in drug development programs, where previously developed drugs are explored for hit and redeveloped into potential therapeutic agents for new diseases. Globally, in any drug development progra
Synthesis of O-Sulfated Human Syndecan-1-like Glyco-polypeptides by Incorporating Peptide Ligation and O-Sulfated Glycopeptide Cassette Strategies
Huang, Xuefei,Li, Tianlu,Ramadan, Sherif,Yang, Weizhun
, p. 6429 - 6433 (2020)
A successful synthesis of O-sulfated syndecan-1-like (Q23-E120) glyco-polypeptide was accomplished. The synthesis features the integration of an O-sulfated carbohydrate-bearing glycopeptide cassette with efficient protein ligation strategies, overcoming the acid lability of carbohydrate sulfates as a major hurdle in solid-phase peptide synthesis. Crucial to the synthesis is the microwave-assisted Ag(I) ligation, which afforded the ligation product in improved overall yield. This O-sulfated syndecan-1 (Q23-E120) is the longest O-sulfated glyco-polypeptide prepared to date.
New Vanadium(v) Complexes with Salicylaldehyde Semicarbazone Derivatives: Synthesis, Characterization, and in vitro Insulin-Mimetic Activity - Crystal Structure of [VVO2(salicylaldehyde semicarbazone)]
Noblia, Pabla,Baran, Enrique J.,Otero, Lucia,Draper, Patricia,Cerecetto, Hugo,Gonzalez, Mercedes,Piro, Oscar E.,Castellano, Eduardo E.,Inohara, Toshifumi,Adachi, Yusuke,Sakurai, Hiromu,Gambino, Dinorah
, p. 322 - 328 (2004)
The new dioxo(semicarbazone)vanadium(v) complexes cis-VO2L, where L = salicylaldehyde semicarbazone (L1), salicylaldehyde 4-n-butylsemicarbazone (L2), or salicylaldehyde 4-(2-naphthyl)semicarbazone (L3), have been synthesized, characterized by 1H and 13C NMR and FTIR spectroscopy and tested for bioactivity as potential insulin-mimetic agents. All dioxovanadium(v) complexes exhibited essentially no in vitro insulin-mimetic activity, but the VO2L2 complex developed activity in the presence of ascorbic acid, similar to that of vanadyl sulfate. The molecular structure of the novel complex VO2L1 has been solved by X-ray diffraction methods. It crystallizes in the tetragonal space group P4 2/n with a = 12.7674(7), c = 11.5308(5) A, and Z = 8. The vanadium atom is in a distorted square-pyramidal coordination, with L 1 acting as a tridentate ligand through its azomethyne nitrogen atom, carbonyl oxygen atom and deprotonated phenol oxygen atom. The coordination sphere is completed by two oxo ligands at cis positions. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
Spectroscopic studies, structural characterization and electrochemical studies of two cobalt (III) complexes with tridentate hydrazone Schiff base ligands: Evaluation of antibacterial activities, DNA-binding, BSA interaction and molecular docking
Fekri, Roghayeh,Salehi, Mehdi,Asadi, Asadollah,Kubicki, Maciej
, (2018)
Co(III) complexes of tridentate Schiff base ligands derived from N-(2-hydroxybenzylideneamino)benzamide (H2L1) and 2-(2-hydroxybenzylidene)hydrazine-1-carboxamide (H2L2) were synthesized and characterized using
Spin-crossover behavior of neutral iron(iii) complexes with salicylaldehyde thio-, seleno- and semicarbazone ligands: Experiment and theoretical analysis
Spitsyna, Nataliya G.,Blagov, Maxim A.,Lazarenko, Vladimir A.,Zorina, Leokadiya V.,Vasiliev, Alexander N.,Krapivin, Vladimir B.,Svetogorov, Roman D.,Maximova, Olga V.,Simonov, Sergey V.,Yagubskii, Eduard B.
, p. 9328 - 9336 (2019)
The iron(iii) complex [Fe(Hsemsal)(semsal)]·3H2O (1) (H2semsal-salicylaldehyde semicarbazone) has been synthesized and characterized by powder and single crystal X-ray diffraction, and magnetic susceptibility measurements. Crystal st
Synthesis, characterization, molecular structure and supramolecular architectures of some copper(II) complexes derived from salicylaldehyde semicarbazone
Salem, Nahed M.H.,Rashad, Amal R.,El Sayed, Laila,Foro, Sabine,Haase, Wolfgang,Iskander, Magdi F.
, p. 231 - 242 (2015)
A series of new copper(II) complexes, [Cu(HSalsc)Cl]·1/2H2O (1), [{Cu(HSalsc)}2(NO3)2][{Cu(HSalsc)}2(NO3)·H2O]NO3 (2), [{Cu(Salsc)}2]H2O (3), [Cu
Salicylaldehyde Semicarbazone-Acetic Acid Hydrogen-Bonded Complex
Abboud, Khalil A.,Summers, Stephen P.,Palenik, Gus J.
, p. 1707 - 1709 (1995)
The crystals of C8H9N3O2*C2H4O2 consist of a one-to-one ratio of salicylaldehyde semicarbazone and acetic acid.Each molecule of salicylaldehyde semicarbazone is joined to an acetic acid molecule by a double hydrogen bond.This arrangement is very similar t
Structure and spectral properties of dinuclear zinc complex containing semicarbazonate ligands
Jing-Lin, Wang,Jiao, Feng,Mei-Ping, Xu,Bin-Sheng, Yang
, p. 1245 - 1249 (2011)
The dinuclear Zn2+ complex [Zn(HSSC)OAc]2·2DMF (H2SSC = salicylaldehyde semicarbazone; HOAc = acetic acid; DMF = N,N-dimethylfomamide) was prepared and structurally characterized by single crystal X-ray. The basic structural unit of the complex is a dinuclear complex [Zn(HSSC)OAc]2 in which the semicarbazone ligand adopts the phenol-imine form. The deprotonated phenol group forms a one-atom bridge between the two zinc centers, and both of the zinc centers are five-coordinated. The local coordination environment of Zn2+ can be approximately considered as square pyramidal. UV spectral studies show that the H 2SSC provides strong binding of Zn2+ in a 1:1 ratio in solution. The conditional binding constant of the complex is lg KZn-L = 12.89 ± 0.76 in 0.05 M Tris-HCl buffer at pH 7.4. The H2SSC exhibits an enhanced fluorescence effect by the addition of Zn2+, and affords an excellent selectivity for Zn2+ under physiological conditions.
Exploring Oxidovanadium(IV) Complexes as YopH Inhibitors: Mechanism of Action and Modeling Studies
Martins, Priscila G. A,Mori, Mattia,Chiaradia-Delatorre, Louise D,Menegatti, Angela C. O,Mascarello, Alessandra,Botta, Bruno,Benítez, Julio,Gambino, Dinorah,Terenzi, Hernán
, p. 1035 - 1040 (2015)
YopH tyrosine phosphatase, a virulence factor produced by pathogenic species of Yersinia, is an attractive drug target. In this work, three oxidovanadium(IV) complexes were assayed against recombinant YopH and showed strong inhibition of the enzyme in the
