303040-12-2Relevant academic research and scientific papers
Discovery of novel phosphonic acid derivatives as new chemical leads for inhibitors of TNF-α production
Matsui, Toshiaki,Takahashi, Shinya,Matsunaga, Naoki,Nakamura, Kazunori,Omawari, Nagashige,Sakai, Masaru,Kamoshima, Wataru,Terai, Kouichiro,Ohno, Hiroyuki,Obata, Takaaki,Nakai, Hisao,Toda, Masaaki
, p. 3807 - 3815 (2007/10/03)
2-(Acylamino)benzylphosphonic acid 6 derived from an artificial substrate of sphingomyelinase was found to show inhibitory activity of TNF-α production. Structural optimization was started with the chemical modification of 6. The discovery of another chem
