303044-44-2

Upstream product

• 145546-15-2 (E,E)-2-(1,3-pentadien-1-yl)-1,3-dithiane 
• 303044-43-1 2-Chloromethyl-4,6-dimethoxy-benzoic acid (R)-1-methyl-2-((2R,3R)-3-vinyl-oxiranyl)-ethyl ester 
• 303044-39-5 ethyl (2E,5R)-5-{[(tert-butyl)(diphenyl)silyl]oxy}hex-2-enoate 
• 303044-41-9 (2R,3R)-3-{(2R)-2-{[(1,1-dimethylethyl)diphenylsilyl]oxy}propyl}oxirane-2-methanol 
• 303044-42-0 (2R,3R)-2-{(2R)-2-{[(1,1-dimethylethyl)diphenylsilyl]oxy}propyl}-3-ethenyloxirane 
• 303044-40-8 (2E,5R)-5-{[(1,1-dimethylethyl)diphenylsilyl]oxy}hex-2-en-1-ol 
• 303044-46-4 (-)-(2R,3R,5R)-5-(tert-butyldiphenylsilyloxy)-2,3-(oxiranyl)-hexan-1-al 
• 303044-37-3 2-(chloromethyl)-4,6-dimethoxy-benzoic acid 
• 303044-38-4 (+)-(3R,4R,6R)-6-(hydroxy)-3,4-(oxiranyl)-hept-1-ene 
• 166322-67-4 2-(chloromethyl)-4,6-dimethoxy-benzaldehyde 
• 705-76-0 3,5-dimethoxybenzyl alcohol 
• 142-83-6 trans,trans-2,4-Hexadienal 

Relevant academic research and scientific papers

Concise asymmetric syntheses of radicicol and monocillin I

Radicicol (1) exhibits potent anticancer properties in vitro, which are likely to be mediated through its high affinity (20 nM) for the molecular chaperone Hsp90. Recently, we reported the results of a synthetic program targeting radicicol (1) and monocil

Efficient asymmetric synthesis of radicicol dimethyl ether: a novel application of ring-forming olefin metathesis.

A concise, stereospecific synthesis of radicicol dimethyl ether is presented. The strategy relies on a convergent three-stage assembly of the 14-membered lactone which has, as a key transformation, a novel ring-forming metathesis reaction utilizing a viny