303049-75-4

Usage

Uses

Used in Pharmaceutical Industry:
Bupropion is utilized as an antidepressant medication for the treatment of major depressive disorder. It is employed due to its ability to increase the levels of dopamine and norepinephrine in the brain, which are neurotransmitters associated with mood regulation and the central nervous system's reward pathway.
Used in Smoking Cessation Aids:
In the healthcare sector, bupropion serves as a smoking cessation aid, helping individuals quit smoking by reducing cravings and withdrawal symptoms associated with nicotine dependence. Its stimulant properties and effect on neurotransmitters contribute to its efficacy in this application.
Used in Extended-Release Formulations:
Bupropion is used in extended-release tablet forms to provide a longer-lasting effect, which is beneficial for managing symptoms of depression and nicotine cravings over an extended period without the need for frequent dosing.

Upstream product

• 2354-91-8 N-<(R)-(+)-α-phenylethyl>-2,2,2-trifluoroacetamide 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 

Relevant academic research and scientific papers

Asymmetric synthesis of planar chiral (arene)tricarbonylchromium complexes via enantioselective deprotonation by conformationally constrained chiral Lithium-amide bases

Enantioselective lithiation/electrophile addition reactions with eight chiral Li-amide bases, 1-8, and five [Cr(arene)(CO)3] complexes, 9-13, were investigated. Restriction of conformational freedom in the chiral Li-amide base Li-1, in general, did not result in an increase in asymmetric induction. A new route to enantiomerically enriched (75-92%) planar chiral ortho-substituted benzaldehyde complexes via enantioselective lithiation of benzaldimine complexes 16 and 17 is reported. Within the (1S)-enantiomer series of o-substituted benzaldehyde complexes 18a-d, the sign of the specific rotation, [α](D)/20, is found to be positive, except for the trimethylstannyl derivative 18b. This is interpreted in terms of a reversed conformation of the aldehyde group.

Stereoselective reactions. XXXII. Enantioselective deprotonation of 4- tert-butylcyclohexanone by fluorine-containing chiral lithium amides derived from 1-phenylethylamine and 1-(1-naphthyl)ethylamine

Enantioselective deprotonation of 4-tert-butylcyclohexanone was examined using 1-phenylethylamine- and 1-(1-naphthyl)ethylamine-derived chiral lithium amides having an alkyl or a fluoroalkyl substituent at the amide nitrogen. The lithium amides having a 2,2,2-trifluoroethyl group on the amide nitrogen are easily accessible in both enantiomeric forms, and were found to induce good enantioselectivity in the present reaction.

Enantioselective deprotonation of 4-tert-butylcyclohexanone by fluorine-containing chiral lithium amides derived from α-phenethylamine

An α-phenethylamine-derived chiral lithium amide ((R)-5c) possessing a 2,2,2-trifluoroethyl group on the amide nitrogen was found to induce high enantioselectivity in the kinetic deprotonation of 4-tert-butylcyclohexanone (1) in the presence of excess tri