2354-91-8

Basic information

• Product Name: N-<(R)-(+)-α-phenylethyl>-2,2,2-trifluoroacetamide
• CAS NO: 2354-91-8
• Molecular Weight: 217.191
• Mol File: 2354-91-8.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: N-<(R)-(+)-α-phenylethyl>-2,2,2-trifluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-<(R)-(+)-α-phenylethyl>-2,2,2-trifluoroacetamide(2354-91-8)
• EPA Substance Registry System: N-<(R)-(+)-α-phenylethyl>-2,2,2-trifluoroacetamide(2354-91-8)

Safety Data

• Hazardous Substances Data: 2354-91-8(Hazardous Substances Data)

Upstream product

• 929632-72-4 C₁₇H₁₆F₃NO₃S 
• 407-25-0 trifluoroacetic anhydride 
• 62288-65-7 2,2,2-trifluoro-N-(1-phenylvinyl)acetamide 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 76-05-1 trifluoroacetic acid 
• 431-47-0 trifluoroacetic acid-methyl ester 
• 23943-56-8 P,P-diphenyl-N-[(1R)-1-phenylethyl]phosphinic amide 
• 98-86-2 acetophenone 
• 613-91-2 acetophenone oxime 
• 183266-61-7 1-(trifluoroacetyl)benzotriazole 
• 383-63-1 ethyl trifluoroacetate, 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 354-38-1 2,2,2-trifluoroacetamide 

Downstream Products

• 203186-18-9 (S)-2,2,2-trifluoro-N-(1-(4-iodophenyl)ethyl)ethanamide 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 871720-04-6 (R)-N-(1-(4-bromophenyl)ethyl)-2,2,2-trifluoroacetamide 
• 130632-93-8 (-)-diethyl <2,2,2-trifluoro-N-(α-methylbenzyl)acetimidoyl>phosphonate 
• 306297-60-9 4-{4-[1-(S)-(4-iodophenyl)ethyl]-3(S)-methyl-1-piperazinyl}-1-(tert-butoxycarbonyl)piperidine 
• 726188-52-9 (S)-1-[(S)-1-(4-Iodo-phenyl)-ethyl]-2-methyl-4-piperidin-4-yl-piperazine 
• 306297-56-3 (S)-1-[(S)-1-(4-Iodo-phenyl)-ethyl]-6-methyl-piperazine-2,5-dione 
• 306297-58-5 1-[1(S)-4-iodophenylethyl]-2(S)-methylpiperazine 

Relevant articles and documents

Tuning the Circular Dichroism and Circular Polarized Luminescence Intensities of Chiral 2D Hybrid Organic–Inorganic Perovskites through Halogenation of the Organic Ions

Through the incorporation of various halogen-substituted chiral organic cations, the effects of chiral molecules on the chiroptical properties of hybrid organic–inorganic perovskites (HOIPs) are investigated. Among them, the HOIP having a Cl-substituted chiral cation exhibits the highest circular dichroism (CD) and circular polarized luminescence (CPL) intensities, indicating the existence of the largest rotatory strength, whereas the F-substituted HIOP shows the weakest intensities. The observed modulation can be correlated to the varied magnetic transition dipole of HOIPs, which is sensitive to the d-spacing between inorganic layers and the halogen–halogen interaction between organic cations and the inorganic sheets. These counteracting effects meet the optimal CD and CPL intensity with chlorine substitution, rendering the rotatory strength of HOIPs arranged in the order of (ClMBA)2PbI4>(BrMBA)2PbI4>(IMBA)2PbI4>(MBA)2PbI4>(FMBA)2PbI4.

Diastereoselective synthesis of polyfluoroalkylated α-aminophosphonic acid derivatives

The asymmetric synthesis of biorelevant aminophosphonates and aminophosphonic acids bearing trifluoromethyl, tetrafluoroethyl, perfluoropropyl or chlorodifluoromethyl group in the α-position to phosphonyl group is developed. Diastereoselective reduction o

Self-Disproportionation of Enantiomers (SDE) via achiral gravity-driven column chromatography of N-fluoroacyl-1-phenylethylamines

The study of the self-disproportionation of enantiomers (SDE) via gravity-driven achiral column chromatography of a series of N-fluoroacetylated amides derived from 1-phenylethylamine is described. The chromatographic experiments performed with N-fluoroacetylated amides confirmed, that the process of molecular association in solution leading to the SDE manifestation, is sensitive to the fluorine content and type of solvent used. Thus, the two opposite eluting profiles for the same compound were observed in two different eluents. Moreover, the amides bearing perfluoroalkyl groups showed opposite eluting order as compared to the established profile for fluorine-free N-acetyl-1-phenylethylamine.