303110-80-7

Upstream product

• 222555-06-8 ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate 
• 303111-01-5 (Z)-3-(4-furan-2-yl-phenyl)-3-phenyl-prop-2-en-1-ol 
• 303111-00-4 (Z)-3-(4-bromo-phenyl)-3-phenyl-prop-2-en-1-ol 
• 183593-81-9 (Z)-3-(4-bromo-phenyl)-3-phenyl-acrylic acid ethyl ester 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 

Relevant academic research and scientific papers

Compounds, their preparation and use

Disclosed are novel compounds of formula (I) wherein A1, A2, Ar, R5, R6, R8, M, Q, Y, Z, k, m and n are as defined in the specification. These compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR). Such conditions include diabetes and obesity.

Design and synthesis of novel PPARα/γ/δ triple activators using a known PPARα/γ dual activator as structural template

Using a known dual PPARα/γ activator (5) as a structural template, SAR evaluations led to the identification of triple PPARα/γ/δ activators (18-20) with equal potency and efficacy on all three receptors. These compounds could become useful tools for studying the combined biological effects of PPARα/γ/δ activation.