303128-58-7Relevant articles and documents
Boosting the Catalytic Performance of Metal–Organic Frameworks for Steroid Transformations by Confinement within a Mesoporous Scaffold
Cirujano, Francisco G.,Luz, Ignacio,Soukri, Mustapha,Van Goethem, Cedric,Vankelecom, Ivo F. J.,Lail, Marty,De Vos, Dirk E.
supporting information, p. 13302 - 13306 (2017/10/17)
Solid-state crystallization achieves selective confinement of metal–organic framework (MOF) nanocrystals within mesoporous materials, thereby rendering active sites more accessible compared to the bulk-MOF and enhancing the chemical and mechanical stability of MOF nanocrystals. (Zr)UiO-66(NH2)/SiO2 hybrid materials were tested as efficient and reusable heterogeneous catalysts for the synthesis of steroid derivatives, outperforming the bulk (Zr)UiO-66(NH2) MOF. A clear correlation between the catalytic activity of the dispersed Zr sites present in the confined MOF, and the loading of the mesoporous SiO2, is demonstrated for steroid transformations.
Synthesis of steroidal derivatives containing substituted, fused and spiro pyrazolines
Romero-López, Anabel,Montiel-Smith, Sara,Meza-Reyes, Socorro,Merino-Montiel, Penélope,Vega-Baez, José Luis
, p. 86 - 92 (2014/07/08)
An efficient and facile synthesis of fused, substituted and spiro pyrazoline steroid derivatives through a cycloaddition reaction of different α,β-unsaturated ketones with hydrazine acetate in acetic acid is reported. Depending on the starting material, the ring closure reaction provided a mixture of two steroidal pyrazoline epimers that were separated and studied by NMR techniques. In one case it was possible to isolate and characterize the hydrazone derivative as the reaction intermediate, which confirms the mechanism proposed in the literature [11,25,26].2014 Published by Elsevier Inc.
Peracid Oxidation of 16-Arylidene- and 16-Alkylidene-17-oxo-steroids
Chagonda, Lameck S.,Marples, Brian A.
, p. 875 - 880 (2007/10/02)
Peracid oxidation of 16-arylidene- and 16-alkylidene-5α-androstan-17-ones (1) - (6) gave no α,β-unsaturated δ-lactones, but resulted mainly in products of direct oxidation of the olefinic double bond.