30314-01-3

Upstream product

• 3906-07-8 3-(4-methoxyphenyl)-1-phenyl-2-propen-1-ol 
• 123-54-6 acetylacetone 
• 22966-19-4 trans-4'-methoxychalcone 
• 30313-25-8 ethyl 2-oxo-6-(4-methoxyphenyl)-4-phenyl-3-cyclohexene-1-carboxylate 

Downstream Products

• 256491-91-5 3-(4-methoxy-phenyl)-5-phenyl-cyclohexanone 
• 366809-43-0 5-(4-methoxyphenyl)-3-phenyl-1-morpholino-3,4,5,6-tetrahydrobenzene 

Relevant academic research and scientific papers

An efficient iron-catalyzed carbon-carbon single-bond cleavage via retro-claisen condensation: A mild and convenient approach to synthesize a variety of esters or ketones

An efficient iron-salt-catalyzed carbon-carbon bond cleavage occurring through a retro-Claisen condensation reaction has been developed. The reaction is useful for the synthesis of a variety of esters or ketones under mild conditions. This method works under solvent-free conditions without the need of an inert atmosphere. This protocol is also applicable for the one-pot syntheses of ketones through tandem carbon-carbon bond formation (substitution or Michael) followed by a retro-Claisen reaction. However, for Michael adducts, ring annulation takes place subsequently. Notably, this method is very simple, convenient, high yielding, and only a catalytic (5 to 1.0 mol-%) amount of Fe(OTf)3 is needed.

Cyclohexenone carboxylates. A versatile source for fused isoxazoles and pyrazoles

The 6-carbethoxy-3,5-diarylcyclohex-2-enone (1) was subjected to condensation and 1,3-dipolar cycloaddition reactions to get fused isoxazole and pyrazole derivatives.