303144-44-7

Basic information

• Product Name: 1-(2-Pyrimidinyl)piperidine-4-carboxylic acid
• Synonyms: 1-(2-Pyrimidyl)piperidine-4-carboxylic acid;1-Pyrimidin-2-yl-piperidine-4-carboxylicacid95%;1-PYRIMIDIN-2-YL-PIPERIDINE-4-CARBOXYLIC ACID 95%;1-(2-Pyrimidinyl)piperidine-4-carboxylic acid;AKOS BBS-00001573;1-(2-PYRIMIDINYL)-4-PIPERIDINECARBOXYLIC ACID;1-PYRIMIDIN-2-YL-PIPERIDINE-4-CARBOXYLIC ACID;BUTTPARK 90\06-41
• CAS NO: 303144-44-7
• Molecular Formula: C₁₀H₁₃N₃O₂
• Molecular Weight: 207.23
• Product Categories: Carboxylic Acids;Pyrans, Piperidines &Piperazines;Carboxylic Acids;Pyrans, Piperidines & Piperazines
• Mol File: 303144-44-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 103-105°C
• Boiling Point: 434 °C at 760 mmHg
• Flash Point: 216.2 °C
• Appearance: /
• Density: 1.291 g/cm³
• Vapor Pressure: 2.67E-08mmHg at 25°C
• Storage Temp.: 2-8°C
• PKA: 4.16±0.20(Predicted)
• CAS DataBase Reference: 1-(2-Pyrimidinyl)piperidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Pyrimidinyl)piperidine-4-carboxylic acid(303144-44-7)
• EPA Substance Registry System: 1-(2-Pyrimidinyl)piperidine-4-carboxylic acid(303144-44-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 303144-44-7(Hazardous Substances Data)

Usage

General Description

1-(2-Pyrimidinyl)piperidine-4-carboxylic acid is a chemical compound that belongs to the class of organic compounds known as piperidinecarboxylic acids. These are compounds containing a piperidine ring which bears a carboxylic acid group. The molecular structure consists of a piperidine-4-carboxylic acid nucleus which bears a pyrimidine group at the 1-position. The detailed study of the properties, pharmaceutical uses, or synthetic processes of this compound is not largely documented in the scientific literature. Therefore, its physical properties, safety hazards, biological roles, or uses, if any, are not well known. As such, it's always recommended to handle it with adequate safety and precautionary measures until comprehensive data are available.

InChI:InChI=1/C10H13N3O2/c14-9(15)8-2-6-13(7-3-8)10-11-4-1-5-12-10/h1,4-5,8H,2-3,6-7H2,(H,14,15)/p-1

Upstream product

• 1126-09-6 4-carbethoxypiperidine 
• 111247-60-0 1-pyrimidin-2-ylpiperidine-4-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity

The design and synthesis of a new class of nonpeptide direct thrombin inhibitors, built on the structure of 1-(pyridin-4-yl)piperidine-4-carboxamide, are described. Starting from a strongly basic 1-amidinopiperidine derivative (6) showing poor thrombin (fIIa) and factor Xa (fXa) inhibition activities, anti-fIIa activity and artificial membrane permeability were considerably improved by optimizing the basic P1 and the X-substituted phenyl P4 binding moieties. Structure-activity relationship studies, usefully complemented with molecular modeling results, led us to identify compound 13b, which showed excellent fIIa inhibition (Ki = 6 nM), weak anti-Xa activity (K i = 5.64 μM), and remarkable selectivity over other serine proteases (e.g., trypsin). Compound 13b showed in vitro anticoagulant activity in the low micromolar range and significant membrane permeability. In mice (ex vivo), 13b demonstrated anticoagulant effects at 2 h after oral dosing (100 mg·kg-1), with a significant 43% prolongation of the activated partial thromboplastin time (aPTT), over controls (P 0.05).

PIPERIDINE/CYCLOHEXANE CARBOXAMIDE DERIVATIVES FOR USE AS VANILLOID RECEPTOR MODULATORS

Certain compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R1, R2, P, P', X, m and n are as defined in the specification, a process for preparing such compounds, a pharmaceutical composition c