303176-40-1

Basic information

• Product Name: (1’R,2S)-2-(2’-Tosyl-1’,2’-dihydroxyethyl)-6-fluorochromane
• Synonyms: (1’R,2S)-2-(2’-Tosyl-1’,2’-dihydroxyethyl)-6-fluorochromane;(1R)-1-[(2S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-1,2-ethanediol 2-(4-Methylbenzenesulfonate)
• CAS NO: 303176-40-1
• Molecular Formula: C₁₈H₁₉FO₅S
• Molecular Weight: 366.4038632
• Product Categories: Aromatics;Intermediates & Fine Chemicals. Sulfur & Selenium Compounds;Pharmaceuticals
• Mol File: 303176-40-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 103-105 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 540.4±50.0 °C(Predicted)
• Appearance: /
• Density: 1.340±0.06 g/cm3(Predicted)
• Solubility: Chloroform, Dichloromethane, Methanol
• PKA: 13.59±0.20(Predicted)
• CAS DataBase Reference: (1’R,2S)-2-(2’-Tosyl-1’,2’-dihydroxyethyl)-6-fluorochromane(CAS DataBase Reference)
• NIST Chemistry Reference: (1’R,2S)-2-(2’-Tosyl-1’,2’-dihydroxyethyl)-6-fluorochromane(303176-40-1)
• EPA Substance Registry System: (1’R,2S)-2-(2’-Tosyl-1’,2’-dihydroxyethyl)-6-fluorochromane(303176-40-1)

Safety Data

• Hazardous Substances Data: 303176-40-1(Hazardous Substances Data)

Usage

Chemical Properties

Pale Brown Solid

Uses

(-)-Nebivolol intermediates.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 303176-39-8 1-[6-fluoro-(2S)-3,4-dihydro-2H-benzopyran-2-yl]-(1R)-1,2-ethylene glycol 
• 13990-72-2 1-allyloxy-4-fluorobenzene 
• 13997-72-3 1-allyl-2-hydroxy-5-fluorobenzene 
• 303176-35-4 3-(2-tert-butyldimethylsilyloxy-5-fluoro-phenyl)-1-propanol 
• 371-41-5 4-Fluorophenol 
• 797054-19-4 (S)-2-[(R)-2,2-dimethyl-1,3-dioxolan-4-yl]-6-fluoro-2,3-dihydrochromen-4-one 
• 303176-36-5 ethyl 5-(2-tert-butyldimethylsilyloxy-5-fluoro-phenyl)-2-pentenoate 
• 303176-37-6 5-(2-tert-butyldimethylsilyloxy-5-fluoro-phenyl)-(E)-2-penten-1-ol 
• 303176-34-3 2-alllyl-1-(tert-butyldimethylsilyloxy)-4-fluoro-benzene 
• 303176-38-7 5-(5-fluoro-2-hydroxy-phenyl)-E-2-penten-1-ol 
• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 
• 783332-57-0 3-(2-((tert-butyldimethylsilyl)oxy)-5-fluorophenyl)propanal 

Downstream Products

• 303176-42-3 (R)-2-amino-1-[(S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]ethanol 
• 197706-51-7 (S)-6-fluoro-2-((R)-oxiran-2-yl)chroman 
• 152520-56-4 d-nebivolol hydrochloride 
• 118457-14-0 (+)-Nebivolol 

Relevant articles and documents

Synthesis of intermediate compound and [...] (by machine translation)

Synthesis of intermediate compounds [a] and [...]. [Solution] a [...], asymmetric epoxidation, sulfonyl halide in the presence of base catalyst by sulfonation, alkylation of amines, such as synthesized by a series of cross-coupling reaction. [Effect] [...] important from the viewpoint of pharmacological value, high efficiency, low cost, and which meets the requirements of industrial, optical isomers may be prepared [...] and develop a method, which is very economical in social benefit. [Drawing] no (by machine translation)

Nebivolol synthetic method and intermediate compounds of the

The present invention relates to a synthesis method and an intermediate compound of nebivolol. Specifically the invention relates to the method for synthesizing the nebivolol, the intermediate compound of the nebivolol, and a method for preparing the intermediate compound.

PROCESS FOR PREPARING NEBIVOLOL

The present invention relates to a process for preparing nebivolol and, more particularly, to a process for preparing d-nebivolol and its enantiomer /-nebivolol or acid addition salts thereof starting from commercially available or easily obtainable 2,2-dimethyl-l,3 dioxolane-4- carbaldehyde and a vinyl Grignard reagent.