303213-70-9Relevant academic research and scientific papers
Identification of novel quinazolinedione derivatives as RORγt inverse agonist
Fukase, Yoshiyuki,Sato, Ayumu,Tomata, Yoshihide,Ochida, Atsuko,Kono, Mitsunori,Yonemori, Kazuko,Koga, Keiko,Okui, Toshitake,Yamasaki, Masashi,Fujitani, Yasushi,Nakagawa, Hideyuki,Koyama, Ryoukichi,Nakayama, Masaharu,Skene, Robert,Sang, Bi-Ching,Hoffman, Isaac,Shirai, Junya,Yamamoto, Satoshi
, p. 721 - 736 (2018/02/07)
Novel small molecules were synthesized and evaluated as retinoic acid receptor-related orphan receptor-gamma t (RORγt) inverse agonists for the treatment of inflammatory and autoimmune diseases. A hit compound, 1, was discovered by high-throughput screeni
Synthesis and evaluation of new N6-substituted adenosine-5′-N-methylcarboxamides as A3 adenosine receptor agonists
Devine, Shane M.,Gregg, Alison,Figler, Heidi,McIntosh, Kate,Urmaliya, Vijay,Linden, Joel,Pouton, Colin W.,White, Paul J.,Bottle, Steven E.,Scammells, Peter J.
experimental part, p. 3078 - 3087 (2010/07/08)
A number of N6-substituted adenosine-5′-N-methylcarboxamides were synthesised and their pharmacology, in terms of their receptor affinity, selectivity and cardioprotective effects, were explored. The first series of compounds, 4a-4f and 5a-5f,
