3034-54-6

Basic information

• Product Name: 2-IODOTHIAZOLE
• Synonyms: 2-IODOTHIAZOLE;2-iodo-1,3-thiazole
• CAS NO: 3034-54-6
• Molecular Formula: C₃H₂INS
• Molecular Weight: 211.02
• Product Categories: Sulphur Derivatives;Thiazoles
• Mol File: 3034-54-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 232.5 °C at 760 mmHg
• Flash Point: 94.4 °C
• Appearance: /
• Density: 2.239 g/cm³
• Vapor Pressure: 0.0896mmHg at 25°C
• Refractive Index: 1.68
• PKA: 0.90±0.10(Predicted)
• CAS DataBase Reference: 2-IODOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-IODOTHIAZOLE(3034-54-6)
• EPA Substance Registry System: 2-IODOTHIAZOLE(3034-54-6)

Safety Data

• Hazardous Substances Data: 3034-54-6(Hazardous Substances Data)

Usage

Description

2-Iodothiazole, also known as 2-iodo-1,3-thiazole, is a heterocyclic chemical compound with the molecular formula C3H2INS. It features a unique structure that includes both iodine and sulfur atoms, making it a versatile building block in synthetic chemistry. The presence of these moieties endows 2-iodothiazole with a broad range of potential applications across various industries.

Uses

Used in Pharmaceutical Industry:
2-Iodothiazole is used as a key building block for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Iodothiazole serves as an essential intermediate in the production of agrochemicals. Its incorporation into the molecular structures of these compounds can enhance their effectiveness in pest control and crop protection.
Used in Organic Compounds Synthesis:
2-Iodothiazole is utilized as a versatile intermediate in the synthesis of a wide range of organic compounds. Its reactivity and structural features make it a valuable component in the creation of new molecules with diverse applications in various fields.
Used in Chemical Manufacturing:
As an intermediate in chemical manufacturing, 2-Iodothiazole plays a crucial role in the production of various chemicals. Its presence in the synthesis process can improve the properties of the final products, such as stability, reactivity, or specific functional groups required for particular applications.

InChI:InChI=1/C3H2INS/c4-3-5-1-2-6-3/h1-2H

Upstream product

• 288-47-1 1,3-thiazole 
• 96-50-4 2-thiazolylamine 
• 71777-92-9 2,4,6-triphenyl-1-thiazol-2-yl-pyridinium; iodide 

Downstream Products

• 58822-97-2 2-azido-1,3-thiazole 
• 1401249-75-9 (5R,7S)-1-(3-fluorophenyl)-8-(3-isopropoxybenzyl)-7-methyl-3-(1,3-thiazol-2-yl)-2-thia-1,3,8-triazaspiro[4.5]decane 2,2-dioxide 
• 1007351-22-5 C₂₄H₂₄N₂O₂S 
• 1007351-43-0 C₂₅H₂₆N₂O₂S 
• 1007351-66-7 C₂₅H₂₆N₂O₃S 
• 1007351-78-1 C₂₆H₂₈N₂O₄S 
• 154787-38-9 1-Phenylsulfonyl-3-thiazol-2-ylindole 
• 35070-01-0 2-(2-phenylethynyl)thiazole 

Relevant articles and documents

Design and characterization of a heterocyclic electrophilic fragment library for the discovery of cysteine-targeted covalent inhibitors

A fragment library of electrophilic small heterocycles was characterized through cysteine-reactivity and aqueous stability tests that suggested their potential as covalent warheads. The analysis of theoretical and experimental descriptors revealed correlations between the electronic properties of the heterocyclic cores and their reactivity against GSH that are helpful in identifying suitable fragments for cysteines with specific nucleophilicity. The most important advantage of these fragments is that they show only minimal structural differences from non-electrophilic counterparts. Therefore, they could be used effectively in the design of targeted covalent inhibitors with minimal influence on key non-covalent interactions.

Deprotonative metalation of five-membered aromatic heterocycles using mixed lithium-zinc species

(Equation Presented) Deprotonation of benzoxazole, benzothiazole, benzo[b]thiophene, benzo[b]furan, N-Boc-protected indole and pyrrole, and N-phenylpyrazole using an in situ mixture of ZnCl2·TMEDA (0.5 equiv) and lithium 2,2,6,6-tetramethylpipe

Synthesis of High Carbon Materials from Acetylenic Precursors. Preparation of Aromatic Monomers Bearing Multiple Ethynyl Groups

The synthesis of polyethynyl aromatics as starting materials for the preparation of highly cross-linked organic solids containing high atom fractions of carbon is described.Treatment of bromo- and iodoaromatic compounds with (trimethylsilyl)acetylene (TMSA) in the presence of palladium(O) and copper(I) in amine solvents yields (trimethylsilyl)ethynyl-substituted aromatics.The TMS protecting groups can be removed by hydrolysis with mild base.Compounds prepared by using this technique include 1,3-diethynylbenzene, 2,5-diethynylthiophene, 1,3-diethynyltetrafluorobenzene, 1,4-diethynyltetrafluorobenzene, 2-ethynylthiazole, 2,4-diethynylthiazole, 2,7-diethynylnaphthalene, hexakis((trimethylsilyl)ethynyl)benzene, tetraethynylthiophene, 2,5-bis((trimethylsilyl)ethynyl)-3,4-bis(3-hydroxy-3-methyl-1-butynyl)thiophene, 2,5-diethynyl-3,4-bis(3-hydroxy-3-methyl-1-butynyl)thiophene, 2,5-bis(4-(2-thienyl)butadiynyl)-3,4-bis(3-hydroxy-3-methyl-1-butynyl)thiophene, and 2,5-bis-(4-(2-thienyl)butadiynyl)-3,4-diethynylthiophene.