35070-01-0Relevant articles and documents
Ligand-free Pd/Ag-mediated dehydrogenative alkynylation of imidazole derivatives
Bellina, Fabio,Biagetti, Matteo,Fausti, Mattia,Guariento, Sara,Lessi, Marco,Ronchi, Paolo,Rosadoni, Elisabetta
, p. 25504 - 25509 (2021/08/03)
A variety of 2-alkynyl(benzo)imidazoles have been synthesized by dehydrogenative alkynylation of (benzo)imidazoles with terminal alkyne in NMP under air in the presence of Ag2CO3as the oxidant and Pd(OAc)2as the catalyst precursor. The data obtained in this study support a reaction mechanism involving a non-concerted metalation deprotonation (n-CMD) pathway.
A straightforward alkynylation of Li and Mg metalated heterocycles with sulfonylacetylenes
Marzo, Leyre,Prez, Ignacio,Yuste, Francisco,Alemn, Jos,Garca Ruano, Jos Luis
supporting information, p. 346 - 349 (2015/02/05)
Coupling of alkynyl moieties to heterocyclic rings, without using transition metals, can be easily performed by the reaction of aryl or heteroaryl sulfonylacetylenes with heteroaryl-Li compounds or their corresponding less reactive magnesium derivatives.
Synthesis of internal alkynes through the Pd-catalyzed coupling of heteroaryl halides with terminal alkynes
Lu, Linhua,Yan, Hong,Sun, Peng,Zhu, Yan,Yang, Hailong,Liu, Defu,Rong, Guangwei,Mao, Jincheng
supporting information, p. 1644 - 1648 (2013/04/10)
Sonogashira-type cross-couplings of functionalized heterocyclic halides with terminal alkynes were performed efficiently at room temperature. The heteroaryl halides were easily prepared from the corresponding heterocyclic compounds. The catalytic system tolerated a very broad scope of substrates; oxazoles, thiazoles, and furans participate in this type of reaction for the first time. This reaction provides an efficient method for the direct functionalization of heterocycles. Sonogashira-type cross-coupling of functionalized heterocyclic halides with terminal alkynes are performed efficiently at room temperature. The catalytic system tolerates a very broad scope of substrates; oxazoles, thiazoles, and furans participate in this type of reaction for the first time. The reaction provides an efficient method for the direct functionalization of heterocycles. Copyright