30359-14-9

Upstream product

• 78-94-4 methyl vinyl ketone 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 26480-63-7 4t-(4-nitro-phenyl)-but-3-en-2-one-(2,4-dinitro-phenylhydrazone) 
• 146537-90-8 2-[4-((2,4-dimethylthiazol-5-yl)methyl)phenylaminocarbonyl]benzoic acid 
• 146537-89-5 2,4-dimethyl-5-(4-aminobenzyl)thiazole 
• 946-49-6 (E)-4-(4-nitrophenyl)-3-buten-2-one 

Relevant academic research and scientific papers

Thiazole derivatives which are angiotensin II receptor antagonists, their methods of preparation and pharmaceutical compositions in which they are present

The present invention relates to the derivatives of formula (I): STR1 and their addition salts, and to their use in therapeutics, especially for the treatment of cardiovascular diseases and in particular for the treatment of hypertension and cardiac insufficiency.

Process for the arylation of olefines

A process for arylating an olefinic compound by addition of an aryl group to a double bond of said olefinic compound consisting in diazotizing an arylamine in an aqueous acidic solution comprising a lower alkanoic acid to form a solution of an aryldiazonium salt and reacting said aryldiazonium salt solution with an olefinic compound in an organic solvent in the presence of a catalytically effective amount of a copper halide. The amount of alkanoic acid is about 15 to 37% by volume of the total solvents used. The alkanoic acid is preferably acetic acid and the copper halide cuprous chloride.