30361-18-3

Basic information

• Product Name: 3.5-Di-O-benzoyl-2-C-methyl-α-D-ribofuranose
• Synonyms: 3.5-Di-O-benzoyl-2-C-methyl-α-D-ribofuranose
• CAS NO: 30361-18-3
• Molecular Weight: 372.375
• Mol File: 30361-18-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3.5-Di-O-benzoyl-2-C-methyl-α-D-ribofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 3.5-Di-O-benzoyl-2-C-methyl-α-D-ribofuranose(30361-18-3)
• EPA Substance Registry System: 3.5-Di-O-benzoyl-2-C-methyl-α-D-ribofuranose(30361-18-3)

Safety Data

• Hazardous Substances Data: 30361-18-3(Hazardous Substances Data)

Upstream product

• 729596-46-7 3,5-di-O-benzoyl-2-C-methyl-D-ribono-γ-lactone 
• 492-30-8 2-C-methyl-D-ribono-1,4-lactone 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1199809-23-8 ((2R,3R,4R,5R)-3-(benzoyloxy)-5-chloro-4-fluoro-4-methyltetrahydrofuran-2-yl)methyl benzoate 
• 817204-32-3 (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl benzoate 
• 15397-15-6 1,2,3,5-tetra-O-benzoyl-2-C-methyl-β-D-ribofuranose 
• 23643-36-9 2′,3′,5′-tri-O-benzoyl-2′-C-methyluridine 

Relevant articles and documents

Technology for preparing sofosbuvir intermediate

A technology for preparing a sofosbuvir intermediate represented by formula 1 comprises the following steps: (a) reducing a compound 2 by sodium borohydride to generate a compound 3; (b) reacting thecompound 3 with a methanol-hydrochloric acid solution to generate a compound 4; (c) carrying out a fluorination reaction on the compound 4 and a fluorination reagent in a reaction solvent at -10 to -65 DEG C under the protection of nitrogen, and post-treating a reaction solution after the reaction is fully carried out in order to obtain a compound 5; (d) cooling an n-hexane or petroleum ether or cyclohexane solution of the compound 5 to -5-5 DEG C under the protection of nitrogen, adding thionyl chloride, slowly dropwise adding methanol or ethanol at a controlled temperature of -5-5 DEG C, rising the temperature to 10-40 DEG C after the dropwise addition, continuously performing stirring until the reaction is completed , and removing the solvent to obtain a compound 6; and (e) condensing the compound 6 and a compound 7, and carrying out hydrolysis treatment to obtain the target product which is the compound 1. The preparation technology has the characteristics of high yield, convenience and safety in operation, less discharge of three wastes, low production cost, and suitableness for industrial production.

PROCESS FOR THE PREPARATION OF RIBOFURANOSE DERIVATIVES

The present invention relates to a new process in 3 steps starting from 2-C-methyl-D-ribopentono-1,4-lactone for the preparation of tetra-acyl ribofuranose derivatives of Formula (I) useful in the synthesis of nucleotides.