30368-22-0Relevant academic research and scientific papers
Addition reaction of arylboronic acids to aldehydes and α,β-unsaturated carbonyl compounds catalyzed by conventional palladium complexes in the presence of chloroform
Yamamoto, Tetsuya,Iizuka, Michiko,Takenaka, Hiroto,Ohta, Tetsuo,Ito, Yoshihiko
experimental part, p. 1325 - 1332 (2009/09/28)
Arylboronic acids react with aldehydes and α,β-unsaturated carbonyl compounds in the presence of a base and a catalytic amount of a palladium(0) complex with chloroform, affording the corresponding addition products in good yields, and chiral benzhydrol was obtained with up to 43% e.e. using (S,S)-bppm as a ligand. General palladium complexes have no catalytic activity without chloroform. Because chloroform is essential for this reaction, these reactions would be promoted by dichloromethylpalladium(II) species.
Copper-catalyzed enantioselective conjugate addition of Grignard reagents to α,β-unsaturated esters
Lopez, Fernando,Harutyunyan, Syuzanna R.,Meetsma, Auke,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 2752 - 2756 (2007/10/03)
(Chemical Equation Presented) Stable dinuclear Cu complexes have been used to catalyze the conjugate addition of inexpensive and readily available Grignard reagents to acyclic α,β-unsaturated esters. The method provides the correspending β-substituted optically active esters in high yields and with excellent enantioselectivities (see scheme). R3 = cyclohexyl, R 4 = Ph or R3 = Ph, R4 = cyclohexyl.
Biphenyl derivatives, production thereof and uses as medicines
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, (2008/06/13)
The present invention relates to biphenyl derivatives of general formula wherein Rato Rgand n are defined as in claim 1, the isomers and salts thereof, particularly the physiologically acceptable salts thereof, which are valuable inhibitors of the microsomal triglyceride-transfer protein (MTP), medicaments containing these compounds and their use, as well as the preparation thereof.
CuX3Li2-catalysed Conjugate Addition of Dialkylmagnesium Reagents to α,β-Unsaturated Carbonyl Compounds
Reetz, Manfred T.,Kindler, Alois
, p. 2509 - 2510 (2007/10/02)
Copper salts of the type CuX3Li2 (X = halogen) catalyse the conjugate addition of dialkylmagnesium compounds to α,β-unsaturated carbonyl compounds in the presence or absence of Me3SiCl as an additive, the organomagnesium compounds being prepared from α-ol
REGIOSPECIFIC ADDITION OF ORGANOCOPPER REAGENTS TO α,β-UNSATURATED ESTERS
Behforouz, Mohammad,Curran, Timothy T.,Bolan, Joseph L.
, p. 3107 - 3110 (2007/10/02)
Mixed cuprates ArSCu(RMgX)n add rapidly to crotonates and cinnamates to give high yields of Michael adducts.Cuprates of methyl, ethyl, isopropyl, t-butyl, phenyl and vinyl were used.Crotonates give much higher yields of adducts with cuprates using 2-methoxythiophenoxide as a ligand than with those using thiophenoxide.
