303958-10-3

Basic information

• Product Name: (5R,6S,7S,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-2-methoxy-vinyl)-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester
• Synonyms: (5R,6S,7S,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-2-methoxy-vinyl)-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester
• CAS NO: 303958-10-3
• Molecular Weight: 586.755
• Mol File: 303958-10-3.mol

Chemical Properties

• CAS DataBase Reference: (5R,6S,7S,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-2-methoxy-vinyl)-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (5R,6S,7S,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-2-methoxy-vinyl)-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester(303958-10-3)
• EPA Substance Registry System: (5R,6S,7S,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-7-((E)-2-methoxy-vinyl)-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester(303958-10-3)

Safety Data

• Hazardous Substances Data: 303958-10-3(Hazardous Substances Data)

Upstream product

• 518-28-5 podofilox 
• 303958-06-7 8-(tert-butyl-dimethyl-silanyloxy)-7-hydroxymethyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid 
• 303958-09-0 8-(tert-butyl-dimethyl-silanyloxy)-7-hydroxymethyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester 
• 303958-07-8 9-(tert-butyl-dimethyl-silanyloxy)-8-hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 112711-16-7 (5R,5aR,8aR,9R)-9-((tert-butyldimethylsilyl)oxy)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one 
• 69739-34-0 t-butyldimethylsiyl triflate 
• 4009-98-7 (methoxymethyl)triphenylphosphonium chloride 
• 303958-08-9 8-(tert-butyl-dimethyl-silanyloxy)-7-formyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester 

Downstream Products

• 303958-13-6 (5R,6S,7S,8S)-8-Hydroxy-7-(2-hydroxy-ethyl)-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester 
• 303958-11-4 (3aS,4S,5R,10bS)-2-Hydroxy-5-(3,4,5-trimethoxy-phenyl)-2,3,3a,4,5,10b-hexahydro-1,7,9-trioxa-dicyclopenta[a,g]naphthalene-4-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis of picropodophyllin homolactone

Based on a Wittig olefination strategy, the first synthesis of picropodophyllin homolactone 2 is described in nine steps and 30% overall yield from podophyllotoxine 1. The relative configuration of 2 was unambiguously determined using 2D NOESY NMR and a Monte Carlo search protocol. This work corrects the literature on the synthesis of 2. (C) 2000 Elsevier Science Ltd.