303997-39-9Relevant academic research and scientific papers
Synthesis, fungicidal and antibacterial activity of new pyridazine derivatives
Foks, Henryk,Wisterowicz, Krystyna,Miszke, Agnieszka,Brozewicz, Kamil,Wisniewska, Katarzyna,Dabrowska-Szponar, Maria
experimental part, p. 961 - 975 (2009/09/30)
Compounds 1-3 were obtained in the reaction of 3,6-dichloro-pyridazines with phenylacetonitriles in the biphasic system - DMSO/50% NaOH. The chlorine atom was replaced with cycloalkylamino (4-13) and hydrazinyl (23, 24) moiety. These last compounds were condensed with aldehydes (25-34). Pyridazynylphenylacetonitriles were converted into amides 14-18 and thioamides 19-22. In compounds 2, 3 the chlorine atom was replaced with thiophenyl (37, 38) and in compound 1 with thioethyl and thiophenyl (35, 36) functional groups. In the reactions of compounds 1, 2 with ammonium polysulfide thioamides with thiol group (39, 40) and chlorine atom (41, 42) were obtained. Compounds 1-17, 19-43 were screened for antibacterial and fungicidal activities.
