304015-16-5

Upstream product

• 136507-14-7 (2-methoxy-4-nitrophenyl)methanol 
• 131230-76-7 4-[(tert-butyldimethylsilyloxy)methyl]aniline 
• 304015-15-4 2-methoxy-4-nitrobenzyl 4-nitrophenyl carbonate 

Downstream Products

• 304015-18-7 4-({[(2-methoxy-4-nitrobenzyl)oxy]carbonyl}amino)benzyl 4-nitrophenyl carbonate 
• 304015-17-6 2-methoxy-4-nitrobenzyl 4-(hydroxymethyl)phenylcarbamate 

Relevant academic research and scientific papers

Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapy

A series of nitrobenzyl- and nitroimidazolylmethyl carbamate prodrugs of doxorubicin were prepared and evaluated for their potential use in nitroreductase (NTR) mediated gene-directed enzyme prodrug therapy (GDEPT). The carbamate prodrugs and doxorubicin

Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase

Twelve substituted 4-nitrobenzyl carbamate prodrugs of the 5-aminobenz[e]indoline class of DNA minor groove alkylating agents were prepared and tested as prodrugs for gene-directed enzyme prodrug therapy (GDEPT) using a two-electron nitroreductase (NTR) f