30414-82-5

Upstream product

• 64-17-5 ethanol 
• 27387-23-1 5-methoxy-2-bromophenylacetonitrile 
• 86826-93-9 2-(2-bromo-5-methoxyphenyl)acetic acid 
• 19614-12-1 2-bromo-5-methoxybenzyl bromide 

Downstream Products

• 75534-35-9 2-(2-bromo-5-methoxyphenyl)ethan-1-ol 
• 1610054-64-2 ethyl 2-(2-bromo-5-methoxyphenyl)-2-diazoacetate 
• 153683-14-8 2-(2-Bromo-5-methoxyphenyl)-1-iodoethane 
• 247190-67-6 2-bromo-5-methoxyphenethyl methanesulfonate 

Relevant academic research and scientific papers

Role of ortho -substituents on rhodium-catalyzed asymmetric synthesis of β-lactones by intramolecular C-H insertions of aryldiazoacetates

A rhodium-catalyzed asymmetric synthesis of β-lactones via intramolecular C-H insertion into the ester group of aryldiazoacetates has been developed. The β-lactones were synthesized in high yields and with high levels of diastereo- and enantioselectivity.

Synthetic study of hetisine-type aconite alkaloids. Part 1: Preparation of tetracyclic intermediate containing the C14-C20 bond

Full details for the total synthesis of (±)-nominine, a hetisine-type aconite alkaloid, are presented in three parts. Here (part 1), we describe the preparation of the key tetracyclic intermediate 6. Our palladium-catalyzed intramolecular α-arylation was adopted for preparation of the intermediate 4 with an angular formyl group. An acetal-ene reaction was then employed for C14-C20 bond formation to secure 6 from 5. The reaction mechanism of the acetal-ene reaction is discussed, and a method for removal of the 2-hydroxyethyl group from 6 is developed.