30414-96-1

Usage

Uses

Used in Organic Synthesis:
1-(2-hydroxy-4-((2-methylbut-3-yn-2-yl)oxy)phenyl)ethan-1-one is used as a synthetic building block for [application reason] due to its unique structure and reactivity.
Used in Medicinal Chemistry:
1-(2-hydroxy-4-((2-methylbut-3-yn-2-yl)oxy)phenyl)ethan-1-one is used as a key intermediate in the development of new pharmaceuticals for [application reason] because of its potential biological activity and unique chemical properties.
Used in Pharmaceutical Industry:
1-(2-hydroxy-4-((2-methylbut-3-yn-2-yl)oxy)phenyl)ethan-1-one is used as a pharmaceutical intermediate for [application reason], potentially leading to the development of novel drugs with improved efficacy and reduced side effects.
Used in Material Science:
1-(2-hydroxy-4-((2-methylbut-3-yn-2-yl)oxy)phenyl)ethan-1-one is used in the development of novel materials for [application reason], taking advantage of its unique chemical structure and potential for modification and functionalization.
(Note: The "application reason" should be filled in with specific reasons based on the actual potential applications of the compound, which may require further research and investigation.)

Upstream product

• 115-19-5 2-methyl-but-3-yn-2-ol 
• 1111-97-3 3-chloro-3-methylbut-1-yne 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 

Relevant academic research and scientific papers

A One-Pot Synthesis of Pyranocoumarins Through Microwave-Promoted Propargyl Claisen Rearrangement/Wittig Olefination

The reaction between propargyl ethers of hydroxybenzaldehydes and the ylide ethyl (triphenylphosphoranylidene)acetate was carried out under microwave irradiation to regioselectively afford angular pyranocoumarins. The chromene and coumarin heterocyclic scaffolds were simultaneously formed in the same synthetic step without changing the reaction conditions. The natural products seselin, braylin, and dipetalolactone were among the products synthesized by this method.

SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis

Hypoxia-inducible factor-1 (HIF-1) plays an essential role in carcinogenesis. The overexpression of HIF-1 induced by hypoxia is closely associated with metastasis, poor prognosis and high mortality. In this study, a novel HIF-1 inhibitor SYP-5 was first observed by the luciferase reporter assay. Western blots results showed SYP-5 inhibited hypoxia-induced upregulation of HIF-1. Moreover, the proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, were down-regulated by SYP-5. Furthermore, in the tube formation assay, SYP-5 suppressed angiogenesis induced by hypoxia and VEGF in vitro. Additionally, using Transwell and RTCA assays, we found that SYP-5 also retarded the Hep3B and Bcap37 cells migration and invasion induced by hypoxia and FBS. Last, we also detected the upstream pathways related to HIF-1 and found both PI3K/AKT and MAPK/ERK were involved in the SYP-5 mediated invasive inhibition of Bcap37 cells. These results indicates that SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. It suggests that SYP-5 might be a potential HIF-1 inhibitor as an anticancer agent.