30439-19-1Relevant articles and documents
Novel Aryl Piperazine Derivatives With Medical Utility
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Page/Page column 28; 21, (2009/10/01)
This invention provides novel aryl piperazine derivatives having medical utility, in particular as modulators of dopamine and serotonin receptors, preferably the D3, D2-like and 5-HT2 receptor subtypes, and in particular u
Binding of β-carbolines at 5-HT2 serotonin receptors
Grella, Brian,Teitler, Milt,Smith, Carol,Herrick-Davis, Katharine,Glennon
, p. 4421 - 4425 (2007/10/03)
A series of ring-substituted (i.e., methoxy and bromo) 3,4-dihydro- and 1,2,3,4-tetrahydro-β-carbolines was examined at 5-HT2A and 5-HT2C serotonin receptors. Whereas most of the methoxy-substituted derivatives typically displayed affinities similar to their unsubstituted parents, certain (particularly 8-substituted) bromo derivatives displayed enhanced affinity. A binding profile was obtained for selected β-carbolines.