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4H-1-Benzopyran-4-one, 7-methoxy-2-(3,4,5-trimethoxyphenyl)-, also known as Apigenin 7-O-methyl ether or 7-Methoxyapigenin, is a naturally occurring flavonoid compound characterized by a benzopyran-4-one core structure. This specific chemical features a 7-methoxy group and a 3,4,5-trimethoxyphenyl moiety attached to the 2-position of the benzopyran ring. It is commonly found in various plants and has been studied for its potential antioxidant, anti-inflammatory, and anticancer properties. The compound's chemical formula is C20H18O7, and it has a molecular weight of 374.35 g/mol. Apigenin 7-O-methyl ether is known for its ability to modulate various biological processes, making it a subject of interest in pharmaceutical and nutraceutical research.

3044-57-3

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3044-57-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3044-57-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,0,4 and 4 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3044-57:
(6*3)+(5*0)+(4*4)+(3*4)+(2*5)+(1*7)=63
63 % 10 = 3
So 3044-57-3 is a valid CAS Registry Number.

3044-57-3Downstream Products

3044-57-3Relevant academic research and scientific papers

Inhibitory effect of flavonoids on human glutaminyl cyclase

Li, Manman,Dong, Yao,Yu, Xi,Zou, Yongdong,Zheng, Yizhi,Bu, Xianzhang,Quan, Junmin,He, Zhendan,Wu, Haiqiang

, p. 2280 - 2286 (2016/04/26)

Glutaminyl cyclase (QC) plays an important role in the pathogenesis of Alzheimer's disease (AD) and can be a potential target for the development of novel anti-AD agents. However, the study of QC inhibitors are still less. Here, phenol-4′ (R1-), C5-OH (R2-) and C7-OH (R3-) modified apigenin derivatives were synthesized as a new class of human QC (hQC) inhibitors. The efficacy investigation of these compounds was performed by spectrophotometric assessment and the structure-activity relationship (SAR) was evaluated. Molecular docking was also carried out to analyze the binding mode of the synthesized flavonoid to the active site of hQC.

Regioselective synthesis of flavone derivatives via DMAP-catalyzed cyclization of o-alkynoylphenols

Yoshida, Masahito,Fujino, Yuta,Saito, Koya,Doi, Takayuki

experimental part, p. 9993 - 9997 (2012/02/06)

A catalytic amount of DMAP promoted cyclization of o-alkynoylphenols via a 6-endo cyclization mode leading to flavone derivatives in high yields without forming 5-exo cyclized aurone derivatives. Utilizing this method, methoxy substituted flavone and alkyl substituted γ-benzopyranone derivatives were synthesized.

Synthesis of γ-benzopyranone by TfOH-promoted regioselective cyclization of o-alkynoylphenols

Yoshida, Masahito,Fujino, Yuta,Doi, Takayuki

supporting information; experimental part, p. 4526 - 4529 (2011/10/09)

Regioselective cyclization of o-alkynoylphenols forming γ-benzopyranones has been demonstrated. Trifluoromethanesulfonic acid (TfOH) induced 6-endo cyclization of o-alkynoylphenols without forming 5-exo cyclized benzofuranone derivatives to provide the corresponding γ-benzopyranones in high yields.

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