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4H-1-Benzopyran-4-one, 7-methoxy-2-(3,4,5-trimethoxyphenyl)-, also known as Apigenin 7-O-methyl ether or 7-Methoxyapigenin, is a naturally occurring flavonoid compound characterized by a benzopyran-4-one core structure. This specific chemical features a 7-methoxy group and a 3,4,5-trimethoxyphenyl moiety attached to the 2-position of the benzopyran ring. It is commonly found in various plants and has been studied for its potential antioxidant, anti-inflammatory, and anticancer properties. The compound's chemical formula is C20H18O7, and it has a molecular weight of 374.35 g/mol. Apigenin 7-O-methyl ether is known for its ability to modulate various biological processes, making it a subject of interest in pharmaceutical and nutraceutical research.

3044-57-3

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3044-57-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 3044-57-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,0,4 and 4 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 3044-57:
(6*3)+(5*0)+(4*4)+(3*4)+(2*5)+(1*7)=63
63 % 10 = 3
So 3044-57-3 is a valid CAS Registry Number.

3044-57-3Downstream Products

3044-57-3Relevant academic research and scientific papers

Inhibitory effect of flavonoids on human glutaminyl cyclase

Li, Manman,Dong, Yao,Yu, Xi,Zou, Yongdong,Zheng, Yizhi,Bu, Xianzhang,Quan, Junmin,He, Zhendan,Wu, Haiqiang

, p. 2280 - 2286 (2016/04/26)

Glutaminyl cyclase (QC) plays an important role in the pathogenesis of Alzheimer's disease (AD) and can be a potential target for the development of novel anti-AD agents. However, the study of QC inhibitors are still less. Here, phenol-4′ (R1-), C5-OH (R2-) and C7-OH (R3-) modified apigenin derivatives were synthesized as a new class of human QC (hQC) inhibitors. The efficacy investigation of these compounds was performed by spectrophotometric assessment and the structure-activity relationship (SAR) was evaluated. Molecular docking was also carried out to analyze the binding mode of the synthesized flavonoid to the active site of hQC.

Synthesis of γ-benzopyranone by TfOH-promoted regioselective cyclization of o-alkynoylphenols

Yoshida, Masahito,Fujino, Yuta,Doi, Takayuki

, p. 4526 - 4529 (2011/10/09)

Regioselective cyclization of o-alkynoylphenols forming γ-benzopyranones has been demonstrated. Trifluoromethanesulfonic acid (TfOH) induced 6-endo cyclization of o-alkynoylphenols without forming 5-exo cyclized benzofuranone derivatives to provide the corresponding γ-benzopyranones in high yields.

Regioselective synthesis of flavone derivatives via DMAP-catalyzed cyclization of o-alkynoylphenols

Yoshida, Masahito,Fujino, Yuta,Saito, Koya,Doi, Takayuki

, p. 9993 - 9997 (2012/02/06)

A catalytic amount of DMAP promoted cyclization of o-alkynoylphenols via a 6-endo cyclization mode leading to flavone derivatives in high yields without forming 5-exo cyclized aurone derivatives. Utilizing this method, methoxy substituted flavone and alkyl substituted γ-benzopyranone derivatives were synthesized.

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