3044-57-3

Upstream product

• 1322775-70-1 C₁₉H₂₀O₆ 
• 1322774-81-1 5-methoxy-2-[3-(3,4,5-trimethoxyphenyl)propynoyl]phenol 
• 66922-84-7 7-hydroxy-2-(3,4,5-trimethoxyphenyl)-4H-chromen-4-one 
• 74-88-4 methyl iodide 
• 25015-92-3 2-chloro-1-(2,4-dihydroxyphenyl)ethanone 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 755722-84-0 imine 
• 108-46-3 recorcinol 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 77-78-1 dimethyl sulfate 
• 76968-30-4 1,3-Dioxo-1-(2-hydroxy-4-methoxyphenyl)-3-(3,4,5-trimethoxyphenyl)-propane 

Relevant academic research and scientific papers

Inhibitory effect of flavonoids on human glutaminyl cyclase

Glutaminyl cyclase (QC) plays an important role in the pathogenesis of Alzheimer's disease (AD) and can be a potential target for the development of novel anti-AD agents. However, the study of QC inhibitors are still less. Here, phenol-4′ (R1-), C5-OH (R2-) and C7-OH (R3-) modified apigenin derivatives were synthesized as a new class of human QC (hQC) inhibitors. The efficacy investigation of these compounds was performed by spectrophotometric assessment and the structure-activity relationship (SAR) was evaluated. Molecular docking was also carried out to analyze the binding mode of the synthesized flavonoid to the active site of hQC.

Synthesis of γ-benzopyranone by TfOH-promoted regioselective cyclization of o-alkynoylphenols

Regioselective cyclization of o-alkynoylphenols forming γ-benzopyranones has been demonstrated. Trifluoromethanesulfonic acid (TfOH) induced 6-endo cyclization of o-alkynoylphenols without forming 5-exo cyclized benzofuranone derivatives to provide the corresponding γ-benzopyranones in high yields.

Regioselective synthesis of flavone derivatives via DMAP-catalyzed cyclization of o-alkynoylphenols

A catalytic amount of DMAP promoted cyclization of o-alkynoylphenols via a 6-endo cyclization mode leading to flavone derivatives in high yields without forming 5-exo cyclized aurone derivatives. Utilizing this method, methoxy substituted flavone and alkyl substituted γ-benzopyranone derivatives were synthesized.