304436-18-8Relevant academic research and scientific papers
Asymmetric synthesis of (+)-febrifugine and (+)-isofebrifugine using yeast reduction
Takeuchi, Yasuo,Azuma, Kumiko,Takakura, Kentaro,Abe, Hitoshi,Kim, Hye-Sook,Wataya, Yusuke,Harayama, Takashi
, p. 1213 - 1218 (2001)
The antimalarial agents febrifugine (D-1) and isofebrifugine (D-2) were synthesized from chiral 3-piperidinol (D-4), which was asymmetrically prepared by the yeast reduction of 3-piperidone derivatives (DL-3), with dynamic optical resolution.
Asymmetric synthesis of febrifugine and isofebrifugine using yeast reduction
Takeuchi,Azuma,Takakura,Abe,Harayama
, p. 1643 - 1644 (2007/10/03)
The antimalarial agents febrifugine ((+)-1) and isofebrifugine ((+)-2) were asymmetrically synthesized from chiral piperidin-3-ol ((+)-4), which was prepared by the reductive dynamic optical resolution of the 3-piperidone derivatives ((±)-3) using baker's
