304466-90-8

Upstream product

• 100-51-6 benzyl alcohol 
• 304466-89-5 12-(tert-butoxycarbonyl-methyl-amino)-4-methoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carbothioic acid S-methyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 694491-81-1 C₄₉H₅₉N₆O₁₀C₈H₇O₂CH₂ 
• 675129-55-2 C₅₂H₆₄N₆O₁₂ 
• 675129-56-3 C₅₂H₆₄N₆O₁₂ 
• 675129-54-1 C₅₂H₆₄N₆O₁₂ 
• 675129-58-5 C₄₇H₅₆N₆O₁₀ 
• 675129-59-6 C₄₇H₅₆N₆O₁₀ 
• 675129-57-4 C₄₇H₅₆N₆O₁₀ 
• 122546-77-4 12-({2-[2-{[2-(2-amino-acetylamino)-propionyl]-methyl-amino}-3-(4-methoxy-phenyl)-propionylamino]-propionyl}-methyl-amino)-4-methoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carboxylic acid 
• 675129-62-1 12-({[2-{[2-(2-amino-propionylamino)-propionyl]-methyl-amino}-3-(4-methoxy-phenyl)-propionylamino]-acetyl}-methyl-amino)-4-methoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carboxylic acid 
• 675129-61-0 12-({2-[2-{[(2-amino-propionylamino)-acetyl]-methyl-amino}-3-(4-methoxy-phenyl)-propionylamino]-propionyl}-methyl-amino)-4-methoxy-10-methyl-11-oxo-2-oxa-10-aza-tricyclo[12.2.2.1^3,7]nonadeca-1⁽¹⁷⁾,3⁽¹⁹⁾,4,6,14⁽¹⁸⁾,15-hexaene-9-carboxylic acid 
• 684233-25-8 C₅₃H₆₄N₈O₁₁ 
• 684233-26-9 C₄₆H₅₈N₈O₁₁ 
• 684233-27-0 C₄₁H₅₀N₈O₉ 

Relevant academic research and scientific papers

Degradation of an antitumour bicyclic hexapeptide RA-VII into cycloisodityrosines

Degradation of an antitumour bicyclic hexapeptide, RA-VII 1, produced protected cycloisodityrosines in an efficient manner through bis(thioamide) intermediate 6.

CHEMICAL ENTITIES AND THERAPEUTIC USES THEREOF

The present invention describes the use of translation inhibitors for the treatment of cancer and other disorders. Described herein are translation-inhibiting compounds, and methods of using those compounds for the treatment of cancer and other disorders.

Design and synthesis of a bis(cycloisodityrosine) analogue of RA-VII, an antitumor bicyclic hexapeptide

An analogue of an antitumor bicyclic hexapeptide RA-VII was prepared, in which the Ala-2 and Tyr-3 residues of RA-VII were replaced by a cycloisodityrosine unit. In the crystalline state, the peptide backbone structures and the side-chain conformations at Tyr-3, Tyr-5, and Tyr-6 of this analogue and of RA-II were very similar. This analogue, however, showed much weaker cytotoxicity against P-388 leukemia cells than parent RA-VII.

Synthesis of [Gly-1]RA-VII, [Gly-2]RA-VII, and [Gly-4]RA-VII. Glycine-Containing Analogues of RA-VII, an Antitumor Bicyclic Hexapeptide from Rubia Plants

Three analogues of RA-VII (1), an antitumor bicyclic hexapeptide from Rubia plants, were synthesized. Three analogues, [Gly-1]RA-VII (4), [Gly-2]RA-VII (5), and [Gly-4]RA-VII (6), in which one of the three alanine residues in 1 was replaced by a glycine r