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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-Methyl-3-p-tolyl-1H-pyrazole-4-carbaldehyde serves as a valuable building block in the synthesis of various pharmaceutical and agrochemical products. Its unique structure allows for the creation of a wide range of compounds with potential therapeutic and pesticidal properties.
Used in Organic Synthesis:
As a reagent in organic synthesis, 1-Methyl-3-p-tolyl-1H-pyrazole-4-carbaldehyde is particularly useful in the preparation of heterocyclic compounds. Its versatile chemical structure facilitates the formation of complex molecules that can be further utilized in various chemical and biological applications.
Used in Research and Development:
Due to its demonstrated biological activity, 1-Methyl-3-p-tolyl-1H-pyrazole-4-carbaldehyde is also used in research and development for exploring its potential pharmaceutical applications. This includes studying its interactions with biological systems and assessing its efficacy and safety as a potential therapeutic agent.

Upstream product

• 122-00-9 para-methylacetophenone 
• 3352-98-5 p-methyl acetophenone semicarbazone 
• 350988-62-4 3-(p-tolyl)-1H-pyrazole-4-carboxaldehyde 
• 74-88-4 methyl iodide 

Relevant academic research and scientific papers

Synthesis and the interaction of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines with telomeric DNA as lung cancer inhibitors

A novel series of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines were designed, synthesized and evaluated for their antitumor activity against lung adenocarcinoma by CCK-8 assay, electrophoretic mobility shift assay (EMSA), UV-melting study, wound healing assay and docking study. These compounds showed good inhibitory activities against lung adenocarcinoma. Especially compound 12c exhibited potential antiproliferative activity against A549?cell line with the half maximal inhibitory concentration (IC50) value of 1.48?μM, which was a more potent inhibitor than cisplatin (IC50?=?12.08?μM) and leading compound 2 (IC50?=?1.69?μM), and the maximum cell inhibitory rate being up to 98.40%. Moreover, further experiments demonstrated that compounds 12a–d can strongly interact with telomeric DNA to stabilize G-quadruplex DNA with increased ΔTm values from 12.44 to 20.54?°C at a ratio of DNA to compound 1:10. These results implied that growth inhibition of A549?cells mediated by these phenanthroline derivatives is possibly positively correlated to the fact their interaction with telomeric G-quadruplexs.

Reactions of acetophenonmonomethyl- and -dimethylhydrazones with the Vilsmeier-Reagent; formation of pyrazol-4-carbiminium salts: A contribution to the mechanism

Kira discovered the formation of (4e) N,N-Dimethyl-N-[1,3-diphenylpyrazol-4-ylmethylen]ammonium perchlorat by the reaction from acetophenonphenylhydrazone 1e with the Vilsmeier-Reagent 2. On the example of the Acetophenonmonomethylhydrazone 1a we represen