3352-98-5

Basic information

• Product Name: (1E)-1-(4-methylphenyl)ethanone semicarbazone
• Synonyms: (2E)-2-[1-(4-methylphenyl)ethylidene]hydrazinecarboxamide
• CAS NO: 3352-98-5
• Molecular Formula: C₁₀H₁₃N₃O
• Molecular Weight: 191.2297
• Mol File: 3352-98-5.mol
• Article Data: 7

Chemical Properties

• Density: 1.147g/cm³
• Refractive Index: 1.568
• CAS DataBase Reference: (1E)-1-(4-methylphenyl)ethanone semicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: (1E)-1-(4-methylphenyl)ethanone semicarbazone(3352-98-5)
• EPA Substance Registry System: (1E)-1-(4-methylphenyl)ethanone semicarbazone(3352-98-5)

Safety Data

• Hazardous Substances Data: 3352-98-5(Hazardous Substances Data)

Usage

General Description

(1E)-1-(4-methylphenyl)ethanone semicarbazone is a chemical compound that is commonly used in the field of organic chemistry. It is a semicarbazone derivative of 4-methylphenyl ethanone, also known as p-tolyl ethanone. Semicarbazones are compounds that are commonly used in the synthesis of various organic compounds and pharmaceuticals. They are also used as reagents in chemical reactions and as building blocks in the preparation of complex molecules. This particular compound has potential applications in medicinal chemistry as well as in the development of new materials. Its chemical structure and properties make it a valuable tool for researchers and chemists working in various scientific fields.

Upstream product

• 4426-72-6 hydrazine carboxamide 
• 122-00-9 para-methylacetophenone 
• 563-41-7 semicarbazide hydrochloride 

Downstream Products

• 350988-62-4 3-(p-tolyl)-1H-pyrazole-4-carboxaldehyde 
• 65299-38-9 Potassium; p-tolyl-ethyneselenolate 
• 27892-74-6 4-(p-tolyl)-1,2,3-selenadiazole 
• 304477-41-6 1-methyl-3-(p-tolyl)-1H-pyrazole-4-carbaldehyde 
• 1029475-63-5 1-amino-5-(4-methylbenzoyl)-4-(4-methylphenyl)-1H-pyrimidine-2-one 
• 405880-40-2 Mn(CH₃C₆H₄C(CH₃)NNHC(O)NH₂)2Cl₂ 
• 405880-46-8 Mn(CH₃C₆H₄C(CH₃)NNHC(O)NH₂)2Br₂ 
• 879996-84-6 C₁₇H₂₆N₂O₂Si₂ 
• 879996-66-4 3-p-tolyl-1H-pyrazole-4-carboxylic acid 

Relevant articles and documents

Synthesis of lathyrane diterpenoid nitrogen-containing heterocyclic derivatives and evaluation of their anti-inflammatory activities

As our ongoing work on lathyrane diterpenoid derivatization, three series of lathyrane diterpenoid derivatives were designed and synthesized based combination principles, including pyrazole, thiazole and furoxan moieties. Biological evaluation indicated t

Synthesis and the interaction of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines with telomeric DNA as lung cancer inhibitors

A novel series of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines were designed, synthesized and evaluated for their antitumor activity against lung adenocarcinoma by CCK-8 assay, electrophoretic mobility shift assay (EMSA), UV-melting study, wound healing assay and docking study. These compounds showed good inhibitory activities against lung adenocarcinoma. Especially compound 12c exhibited potential antiproliferative activity against A549?cell line with the half maximal inhibitory concentration (IC50) value of 1.48?μM, which was a more potent inhibitor than cisplatin (IC50?=?12.08?μM) and leading compound 2 (IC50?=?1.69?μM), and the maximum cell inhibitory rate being up to 98.40%. Moreover, further experiments demonstrated that compounds 12a–d can strongly interact with telomeric DNA to stabilize G-quadruplex DNA with increased ΔTm values from 12.44 to 20.54?°C at a ratio of DNA to compound 1:10. These results implied that growth inhibition of A549?cells mediated by these phenanthroline derivatives is possibly positively correlated to the fact their interaction with telomeric G-quadruplexs.

Preparation of 2-Arylethynylselanylacetonitriles from 4-Aryl-1,2,3-selenadiazoles

Base decomposition of 4-(substituted phenyl)-1,2,3-selenadiazoles at room temperature resulted in 2-(substituted phenyl)-ethynylselenolate anions, which were immediately reacted with bromoacetonitrile to give a series of 2-(substituted phenyl)ethynylselan