304655-64-9

Upstream product

• 87736-74-1 4-(tert-butyldimethylsiloxymethyl)bromobenzene 
• 228267-30-9 (3 R)-N-allyloxycarbonyl-1-(4-hydroxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylamine 
• 228267-27-4 (3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutanol 
• 228267-28-5 (3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylazide 
• 228267-29-6 (3R)-N-allyloxycarbonyl-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylamine 

Downstream Products

• 262846-34-4 (1S,3R)-N-allyloxycarbonyl-1-(4-azidomethylphenyl)-4-tert-butyldimethylsiloxy-3-hydroxybutylamine 
• 262845-98-7 (1R,3R)-N-allyloxycarbonyl-1-(4-azidomethylphenyl)-4-tert-butyldimethylsiloxy-3-hydroxybutylamine 
• 262846-09-3 (2S,4S)-2-[4-(Allyloxycarbonylamino-methyl)-phenyl]-4-mercapto-pyrrolidine-1-carboxylic acid allyl ester 
• 170587-06-1 (2S,4S)-4-acetylthio-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonylpyrrolidine 
• 304655-63-8 allyl (1R,5S,6S)-2-[(3S,5R)-1-allyloxycarbonyl-5-[4-(N-allyloxycarbonylaminomethyl)phenyl]pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylate 
• 263155-24-4 Methanesulfonic acid (1R,3R)-3-allyloxycarbonylamino-3-[4-(allyloxycarbonylamino-methyl)-phenyl]-1-methanesulfonyloxymethyl-propyl ester 
• 170719-60-5 (2R,4S)-4-acetylthio-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonylpyrrolidine 
• 262845-99-8 (2R,4R)-2-[4-(N-allyloxycarbonylaminomethyl)phenyl]-1-allyloxycarbonyl-4-mesyloxypyrrolidine 
• 263155-21-1 (1R,3R)-N-allyloxycarbonyl-1-(4-N-allyloxycarbonylaminomethyl)phenyl-3,4-O-isopropylidene-3,4-dihydroxybutylamine 
• 262845-95-4 (2R,4S)-2-[4-(Allyloxycarbonylamino-methyl)-phenyl]-4-mercapto-pyrrolidine-1-carboxylic acid allyl ester 

Relevant academic research and scientific papers

Discovery of novel trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems

Novel trans-3,5-disubstituted pyrrolidinylthio-1β-methylcarbapenems were designed and synthesized to provide J-111,347 (1a) as the first example of an exceptionally broad-spectrum antibiotic, showing activity against methicillin-resistant Staphyloccocus aureus (MRSA) as well as Pseudomonas aeruginosa. Further derivation of 1a afforded J-111,225 (2a), J-114,870 (3a), and J-114,871 (3b), which showed improved safety profiles and retained broad-spectrum antibacterial activities. Copyright (C) 2000 Elsevier Science Ltd.

Structure-activity relationships of trans-3,5-disubstituted pyrrolidinylthio- 1β-methylcarbapenems. Part 1:J-111,347 and related compounds

1β-Methylcarbapenems having various 3,5-disubstituted pyrrolidinylthio- side chains at C-2 were designed and synthesized. Evaluation of their antibacterial activities indicated that J-111,347 (1a) is the first example of an extremely broad spectrum antibiotic showing activity against methicillin-resistant Staphylococcus aureus (MRSA) as well as Pseudomonas aeruginosa.