304682-75-5

Upstream product

• 5680-79-5 glycine ethyl ester hydrochloride 
• 304682-74-4 2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methylpropanoic acid 
• 304682-73-3 2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2,N,N-trimethylpropanamide 
• 304682-72-2 2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoic acid 
• 304682-71-1 methyl-2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)ethanoate 
• 266338-68-5 rac-2-methyl-2-[(3-hydroxy-2-phenylpropanoyl)amino]propanoic acid 

Downstream Products

• 304682-56-2 2-({2-[(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methyl-1-oxopropyl)amino]-1-oxoethyl}amino)-2,N,N-trimethylpropanamide 
• 304682-76-6 2-[(2-{[2-({2-[(3-hydroxy-1-oxo-2-phenylpropyl)amino]-2-methyl-1-oxopropyl}amino)-1-oxoethyl]amino}-2-methyl-1-oxopropyl)amino]ethanoic acid 

Relevant academic research and scientific papers

Synthesis of conformationally restricted cyclic hexadepsipeptides via direct amide cyclization

Ring closure by direct amide cyclization was used in the synthesis of 19-membered cyclic depsipeptides 27 (Schemes 1 and 3). The linear hexapeptide precursors 4, containing the β-hydroxy acid 3-hydroxy-2-phenylpropanoic acid (Tro), and five α-amino acids of the type Aib, Gly, and Pro, were prepared according to Scheme 2. The α,α-disubstituted α-amino acid Aib was incorporated into the peptide chain via the azirine/oxazolone method, and Gly and Pro were introduced by using the TBTU/HOBt coupling method. The cyclic depsipeptides 27a-27f were obtained in reasonable-to-excellent yields (Scheme 3 and Table 1).