30481-08-4Relevant academic research and scientific papers
Electrochemical Umpolung C-H Functionalization of Oxindoles
Pastor, Miryam,Vayer, Marie,Weinstabl, Harald,Maulide, Nuno
supporting information, p. 606 - 612 (2022/01/12)
Herein, we present a general electrochemical method to access unsymmetrical 3,3-disubstituted oxindoles by direct C-H functionalization where the oxindole fragment behaves as an electrophile. This Umpolung approach does not rely on stoichiometric oxidants and proceeds under mild, environmentally benign conditions. Importantly, it enables the functionalization of these scaffolds through C-O, and by extension to C-C or even C-N bond formation.
α-Heteroarylation of esters, lactones, amides, and lactams by nucleophilic aromatic substitution
Shen, Hong C.,Ding, Fa-Xiang,Colletti, Steven L.
, p. 1447 - 1450 (2007/10/03)
A mild and efficient α-heteroarylation of simple esters and amides was developed via nucleophilic aromatic substitution. The choice of NaHMDS in toluene gave the best results. A tandem α-heteroarylation and hydroxylation protocol using air as the oxidant
Synthesis of 3-Hydroperoxyindolin-2-ones and Oxidation of Sulphides to Sulphoxides by 3-Hyxdroperoxyindolin-2-ones
Nishio, Takehiko
, p. 1717 - 1720 (2007/10/02)
The 3-hydroperoxyindolin-2-ones 2 were prepared in moderate yields by the dye-sensitized photooxidation of the indolin-2-ones 1.The 3-hydroperoxyindolin-2-ones thus obtained oxidized a series of sulphides 4 selectively to the corresponding sulphoxides 5 without further oxidation to the sulphone.
