30482-18-9

Upstream product

• 299180-11-3 N-(1,4-dioxaspiro[4.5]dec-8-ylmethyl)acetamide 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 69947-09-7 1,4-dioxaspiro<4.5>decane-8-carbonitrile 

Downstream Products

• 867023-69-6 4,5,6,7-tetrahydro-2H-indazol-5-ylmethanamine 
• 444199-08-0 (+/-)-4,5,6,7-tetrahydro-2H-izoindol-5-ylmethanamine 
• 372982-83-7 tert-butyl (1R)-2-[(2S)-2-({[(2-amino-5,6,7,8-tetrahydro-6-quinazolinyl)methyl]amino}carbonyl)pyrrolidinyl]1-(3,4-dichlorobenzyl)-2-oxoethylcarbamate 
• 372982-89-3 tert-butyl (1R)-2-[(2S)-2-({[(2-amino-5,6,7,8-tetrahydro-6-quinazolinyl)methyl]amino}carbonyl)pyrrolidinyl]-1-benzhydryl-2-oxoethylcarbamate 
• 372982-81-5 tert-butyl (1R)-1-(3,4-dichlorobenzyl)-2-oxo-2-((2S)-2-{[(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)amino]carbonyl}pyrrolidinyl)ethylcarbamate 
• 372982-86-0 tert-butyl (1R)-1-benzhydryl-2-oxo-2-((2S)-2-{[(4,5,6,7-tetrahydro-2H-indazol-5-ylmethyl)amino]carbonyl}pyrrolidinyl)ethylcarbamate 

Relevant academic research and scientific papers

A general synthetic approach to novel conformationally restricted arginine side chain mimetics

A general synthesis of several novel partially saturated, conformationally restricted heterobicyclic arginine side chain mimetics is described. These compounds are interesting peptidomimetic building blocks for incorporation into trypsin-like serine protease inhibitors.

A general synthesis of novel conformationally restricted arginine side- chain mimetics

6-(Aminomethyl)-5,6,7,8-tetrahydro-2-quinazolinamine and 4,5,6,7- tetrahydro-2H-indazol-5-ylmethan-amine were synthesized as novel conformationally restricted arginine side-chain mimetics, designed for incorporation into trypsin-like serine protease inhibitors. (C) 2000 Elsevier Science Ltd.