304858-45-5 Usage
Uses
Used in Medicinal Chemistry:
1-[(2,4-dimethoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid is used as a potential candidate in medicinal chemistry for its possible biological activity. Its unique molecular structure, including the pyrrolidine ring and the aromatic phenyl group with methoxy substituents, may contribute to its interaction with biological targets, making it a promising compound for the development of new drugs.
Used in Drug Development:
In the field of drug development, 1-[(2,4-dimethoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid is utilized as a starting material or a building block for the synthesis of novel pharmaceutical agents. Its structural features may offer advantages in the design of drugs with improved efficacy, selectivity, and reduced side effects. Further research is required to optimize its properties and evaluate its potential in various therapeutic areas.
Used in Pharmaceutical Research:
1-[(2,4-dimethoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid serves as a valuable tool in pharmaceutical research for understanding the structure-activity relationships of various biologically active compounds. By studying its interactions with different biological targets, researchers can gain insights into the design of more effective and safer drugs. Its unique structural elements, such as the pyrrolidine ring and the aromatic phenyl group, may provide valuable information for the development of new drug candidates with improved pharmacological properties.
Check Digit Verification of cas no
The CAS Registry Mumber 304858-45-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,4,8,5 and 8 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 304858-45:
(8*3)+(7*0)+(6*4)+(5*8)+(4*5)+(3*8)+(2*4)+(1*5)=145
145 % 10 = 5
So 304858-45-5 is a valid CAS Registry Number.
304858-45-5Relevant academic research and scientific papers
PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF
-
Paragraph 0733; 0734; 0735, (2013/04/13)
The present invention provides a pyrazole compound of the following general Formula [1b] having SGLT1 inhibitory activity, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and its pharmaceutical use wherein each symbol is the same as defined in the description
CCR5 antagonists as anti-HIV-1 agents. 1. Synthesis and biological evaluation of 5-oxopyrrolidine-3-carboxamide derivatives
Imamura, Shinichi,Ishihara, Yuji,Hattori, Taeko,Kurasawa, Osamu,Matsushita, Yoshihiro,Sugihara, Yoshihiro,Kanzaki, Naoyuki,Iizawa, Yuji,Baba, Masanori,Hashiguchi, Shohei
, p. 63 - 73 (2007/10/03)
A novel lead compound, N-{3-[4-(4-fluorobenzoyl)piperidin-1-yl]propyl}-1- methyl-5-oxo-N-phenylpyrrolidine-3-carboxamide (1), was identified as a CCR5 antagonist by high-throughput screening using [125I]RANTES and CCR5-expressing CHO cells. The IC50 value of 1 was 1.9 μM. In an effort to improve the binding affinity of 1, a series of 5-oxopyrrolidine-3- carboxamides was synthesized. Introduction of 3,4-dichloro substituents to the central phenyl ring (10i, IC50=0.057 μM; 11b, IC 50=0.050 μM) or replacing the 1-methyl group of the 5-oxopyrrolidine moiety with a 1-benzyl group (12e, IC50=0.038 μM) was found to be effective for improving CCR5 affinity. Compound 10i, 11b, and 12e also inhibited CCR5-using HIV-1 envelope-mediated membrane fusion with IC50 values of 0.44, 0.19, and 0.49 μM, respectively.
