1-[(2,4-dimethoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid

Base Information

• Chemical Name: 1-[(2,4-dimethoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid
• CAS No.: 304858-45-5
• Molecular Formula: C14H17NO5
• Molecular Weight: 279.28800
• Mol file: 304858-45-5.mol

Synonyms:1-(2,4-dimethoxybenzyl)-5-oxo-3-pyrrolidinecarboxylic acid;

Chemical Property of 1-[(2,4-dimethoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid

Chemical Property:

• Melting Point: 122-123 °C(Solv: ethyl ether (60-29-7); 1-propanol (71-23-8))
• Boiling Point: 525.8±50.0 °C(Predicted)
• PKA: 4.49±0.20(Predicted)
• PSA: 76.07000
• Density: 1.300±0.06 g/cm3(Predicted)
• LogP: 1.07480

Purity/Quality:

99%, ^*data from raw suppliers

1-(2,4-Dimethoxybenzyl)-5-Oxo-3-PyrrolidinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-[(2,4-dimethoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid

There total 1 articles about 1-[(2,4-dimethoxyphenyl)methyl]-5-oxopyrrolidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-methylenesuccinic acid (97-65-4,25119-64-6) + 2,4-Dimethoxybenzylamine (20781-20-8) → 1-(2,4-dimethoxybenzyl)-5-oxopyrrolidine-3-carboxylic acid (304858-45-5)

Guidance literature:

DOI:10.1248/cpb.52.63

Reference yield: 50.0%

oxalyl dichloride (79-37-8) + 1-(2,4-dimethoxybenzyl)-5-oxopyrrolidine-3-carboxylic acid (304858-45-5) + N-[3-(4-Benzyl-1-piperidinyl)propyl]-3-chloroaniline dihydrochloride → N-[3-(4-benzyl-1-piperidinyl)propyl]-N-(3-chlorophenyl)-5-oxo-3-pyrrolidinecarboxamide (304858-46-6)

Guidance literature:

oxalyl dichloride; 1-(2,4-dimethoxybenzyl)-5-oxopyrrolidine-3-carboxylic acid; With N,N-dimethyl-formamide; In dichloromethane; for 1.25h;

N-[3-(4-Benzyl-1-piperidinyl)propyl]-3-chloroaniline dihydrochloride; With triethylamine; at -20 - 0 ℃; for 1h;

With trifluoroacetic acid; at 70 ℃; for 4h;

Reference yield:

(S)-4-Benzyl-2-oxazolidinone (90719-32-7) + 1-(2,4-dimethoxybenzyl)-5-oxopyrrolidine-3-carboxylic acid (304858-45-5) → (S)-4-benzyl-3-[(S)-1-(2,4-dimethoxybenzyl)-5-oxopyrrolidine-3-carbonyl]-2-oxazolidinone (1426408-67-4)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; at 20 ℃; for 3h;

upstream raw materials:

2-methylenesuccinic acid

2,4-Dimethoxybenzylamine

Downstream raw materials:

N-[3-(4-benzylpiperidin-1-yl)propyl]-1-(2,4-dimethoxybenzyl)-5-oxo-N-phenylpyrrolidine-3-carboxamide

N-[3-(4-benzyl-1-piperidinyl)propyl]-N-(3-chlorophenyl)-5-oxo-3-pyrrolidinecarboxamide

(S)-1-(2,4-dimethoxybenzyl)-5-oxopyrrolidine-3-carboxylic acid

(S)-4-benzyl-3-[1-(2,4-dimethoxybenzyl)-5-oxopyrrolidine-3-carbonyl]-2-oxazolidinone

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