304867-98-9Relevant academic research and scientific papers
TETRAHYDROQUINOLINES FOR MODULATING THE EXPRESSION OF EXOGENOUS GENES VIA AN ECDYSONE RECEPTOR COMPLEX
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Page 58, (2008/06/13)
This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising:
Synthesis and SAR of cis-1-Benzoyl-1,2,3,4-tetrahydroquinoline ligands for control of gene expression in ecdysone responsive systems
Smith, Howard C.,Cavanaugh, Caitlin K.,Friz, Jennifer L.,Thompson, Christine S.,Saggers, Jessica A.,Michelotti, Enrique L.,Garcia, Javier,Tice, Colin M.
, p. 1943 - 1946 (2007/10/03)
A library of 35 cis-1-benzoyl-2-methyl-4-(phenylamino)-1,2,3,4-tetrahydroquinolines was prepared. The compounds bore various substitutuents on the benzoyl ring, at the 4-position of the phenylamino ring and at the 6-position of the tetrahydroquinoline rin
