256376-65-5

Usage

Uses

1. Used in Pharmaceutical Research:
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile is used as a research compound for the development of stimulators of soluble guanylate cyclase. This application is significant because soluble guanylate cyclase plays a crucial role in regulating vascular tone and blood flow, making it a potential target for treating various cardiovascular and pulmonary diseases.
2. Used in Drug Discovery and Development:
In the field of drug discovery and development, 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile serves as a valuable starting point for designing new drugs with improved efficacy and selectivity. Its unique chemical structure allows for further modification and optimization to target specific biological pathways and receptors.
3. Used in Chemical Synthesis:
1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile can also be utilized as an intermediate in the synthesis of other complex organic molecules. Its versatile structure makes it a useful building block for creating a wide range of compounds with diverse applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
4. Used in Analytical Chemistry:
1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile can be employed as a reference material or standard in analytical chemistry for the development and validation of new analytical methods, such as high-performance liquid chromatography (HPLC), mass spectrometry, and nuclear magnetic resonance (NMR) spectroscopy. Its distinct chemical properties make it suitable for evaluating the performance of these techniques and ensuring accurate and reliable results.

Upstream product

• 1216246-45-5 (2-fluorobenzyl)hydrazine hydrochloride salt 
• 345-35-7 2-fluorobenzyl chloride 
• 49609-84-9 2-Chloronicotinoyl chloride 
• 2942-59-8 2-chloronicotinic acid 
• 557-21-1 zinc(II) cyanide 
• 1313738-72-5 1-(2-fluorobenzyl)-3-iodo-1H-pyrazolo[3,4-b]pyridine 
• 446-48-0 o-fluorobenzyl bromide 
• 117007-52-0 3-iodo-1H-pyrazolo[3,4-b]pyridine 
• 1186608-79-6 2,2,2-trifluoro-1-(2-fluoropyridin-3-yl)ethanone 
• 956010-87-0 3-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridine 
• 372-48-5 2-fluoropyridine 
• 956010-88-1 1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 
• 407-25-0 trifluoroacetic anhydride 
• 256376-62-2 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide 

Downstream Products

• 304874-06-4 methyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbimidate 
• 428854-24-4 2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6- triamine 
• 304874-07-5 ethyl 4-amino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-5-carboxylate 
• 457914-32-8 2-({4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}amino)ethanol 
• 370879-49-5 2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-[(E)-phenyldiazen-1-yl]pyrimidine-4,6-diamine 
• 370879-47-3 N'-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-2-[1-(2-fluoro-benzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-pyrimidine-4,5,6-triamine 
• 956011-33-9 3-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1,2,4-oxadiazole-5(4H)-thione 
• 956011-28-2 3-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-1,2,4-thiadiazol-5(4H)-one 
• 956011-38-4 3-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-1H-1,2,4-triazol-5(4H)-one 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF METHYL 4,6-DIAMINO-2-[L-(2-FHIOROBENZVR)-LH-PYRAZOLO I3,4-BLPVRIDIN-3-VN-5-PYRIMIDINYL(METHVL)CARBAMATE AND ITS POLYMORPHS THEREOF

The present invention relates to process for the preparation of methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-lH-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl(methyl)carbamate and its polymorphs thereof compound of formula-1, represented by the following structur

Preparation method and application of pyrazolo[3, 4-b]pyridine compound intermediate

The invention provides a preparation method and application of a pyrazolo[3, 4-b]pyridine compound intermediate. Specifically, the intermediate structure is shown as formula IV, wherein the groups are defined as the specification and claims. The intermedi

METHOD FOR SYNTHESIZING 1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDINE-3-FORMAMIDINE HYDROCHLORIDE

The present invention relates to the field of chemical synthesis, and in particular to a method for synthesizing 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-formamidine hydrochloride, which is an important intermediate of Riociguat that is an anti-thro

Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b] pyridines as soluble guanylate cyclase stimulators

Novel guanylate cyclase stimulators are disclosed. Design, synthesis, SAR, and pharmacological profile of the compounds are discussed.

Heterocyclic Substituted, Anellated Pyrazole Derivative and its uses

The present application relates to novel heterocyclyl-substituted fused pyrazole derivatives, to processes for their preparation, to their use, alone or in combination, for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.

Novel Combination Containing a Stimulator of Soluble Guanylate Cyclase and a Lipid-Lowering Substance

A combination product which comprises as pharmaceutically active ingredients at least one active ingredient component A and at least one active ingredient component B, where active ingredient component A is a direct soluble guanylate cyclase stimulator of

Substituted pyrazole derivatives

The present invention relates to novel substituted pyrazole derivatives of the general formula (I) in which the substituents R1, R2, R3, A, X and Y are each as defined, and to processes for their preparation and to their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders.

Novel sulfonamide-substituted pyrazolopyridine derivatives

The invention relates to novel pyrazolopyridine derivatives of formula (I) wherein R1 represents H, Cl or NH2, and R2 and R3 form; together with the heteroatoms to which they are bonded, a five to six-membered heterocycle which can be saturated or partially unsaturated, can optionally contain at least one other heteroatom from the group N, O, S and can be optionally substituted. The invention also relates to salts, isomers and hydrates of said derivatives, in the form of stimulators of soluble guanylate cyclase and as agents for treating cardiovascular diseases, hypertonia, thrombo-embolic diseases and ischaemia, sexual dysfunction, inflammations, and diseases of the central nervous system.

Novel carbamate-substituted pyrazolopyridine derivatives

The invention relates to novel pyrazolopyridine derivatives of the formula (I), wherein R1 represents hydrogen or a di-C1-6-alkylaminocarbonyl group, R2 represents a rest of the formula —O—CO—NR3R4, wherein R3 and R4 are the same or different and represen

NOVEL 2,5-DISUBSTITUTED PYRIMIDINE DERIVATIVES

The invention relates to novel 2,5-disubstituted pyrimidine derivatives, which stimulate the soluble guanylate cyclase, method for production and use thereof for the production of medicaments, in particular medicaments for the treatment of central nervous system diseases.