3049-37-4

Upstream product

• 623-27-8 terephthalaldehyde, 
• 2136-75-6 (triphenylphosphoranylidene)acetaldehyde 
• 107399-42-8 3,3'-(1,4-phenylene)dipropanal 
• 77972-48-6 styrene-α,4-dicarbaldehyde 
• 20635-30-7 1,4-bis(diethoxymethyl)benzene 
• 109-92-2 ethyl vinyl ether 

Downstream Products

• 38862-55-4 (2E,4Z)-5-[4-((1Z,3E)-4-Cyano-buta-1,3-dienyl)-phenyl]-penta-2,4-dienenitrile 
• 33230-53-4 4,4'-p-Phenylen-bis- 
• 103278-16-6 4,4'-p-Phenylen-bis-<1-phenyl-1-cyan-butadien-(1,3)> 
• 18189-32-7 all-trans-1,4-Bis-<4-(4-phenylglyoxyloyl-phenyl)-butadien-(1,3)-yl>-benzol 
• 78097-45-7 C₂₈H₃₈N₆O₂ 
• 39003-04-8 (2E,4Z)-5-[4-((1Z,3E)-4-Propoxycarbonyl-buta-1,3-dienyl)-phenyl]-penta-2,4-dienoic acid propyl ester 
• 99763-71-0 4,4'-p-Phenylen-bis- 
• 102315-24-2 5,5'-p-phenylene-di-valeric acid diethyl ester 
• 26707-07-3 (2E,4Z)-5-[4-((1Z,3E)-4-Ethoxycarbonyl-buta-1,3-dienyl)-phenyl]-penta-2,4-dienoic acid ethyl ester 
• 10162-88-6 1,4-Bis-(4-phenyl-butadienyl)-benzol 
• 39022-93-0 C₃₀H₂₆O₂ 
• 38862-54-3 C₂₈H₂₂O₂ 

Relevant academic research and scientific papers

Preparation method of alpha-deuterated olefine aldehyde

The invention relates to a preparation method of alpha-deuterated olefine aldehyde, which comprises the following steps: by taking alpha, beta-olefine aldehyde as a raw material, carrying out a reversible Michael addition mechanism under the action of deuterium water, a nucleophilic reagent and an organic catalyst to obtain an alpha-deuterated olefine aldehyde compound. The method has high selectivity, and does not generate deuterated by-products at other positions. The alpha-deuterated olefine aldehyde compound prepared by the invention has great application value, can be further widely converted to prepare mono (poly) deuterated olefin and derivatives, olefine acid, conjugated olefine aldehyde, eneyne and other compounds, and has important significance in drug synthesis.

Method for preparing olefine aldehyde by catalyzing terminal alkyne or terminal conjugated eneyne and diphosphine ligand used in method

The invention discloses a method for preparing olefine aldehyde by catalyzing terminal alkyne or terminal conjugated eneyne and a diphosphine ligand used in the method. According to the invention, indole-substituted phosphoramidite diphosphine ligand which is stable in air and insensitive to light is synthesized by utilizing a continuous one-pot method, and the indole-substituted phosphoramidite diphosphine ligand and a rhodium catalyst are used for jointly catalyzing to successfully achieve a hydroformylation reaction of aromatic terminal alkyne and terminal conjugated eneyne under the condition of synthesis gas for the first time, so that an olefine aldehyde structure compound can be rapidly and massively prepared, and particularly, a polyolefine aldehyde structure compound which is more difficult to synthesize in the prior art can be easily prepared and synthesized, and a novel method is provided for synthesis and modification of drug molecules, intermediates and chemical products.

Dehydrogenative Synthesis of Linear α,β-Unsaturated Aldehydes with Oxygen at Room Temperature Enabled by tBuONO

Synthesis of linear α,β-unsaturated aldehydes via a room-temperature oxidative dehydrogenation has been realized by the cocatalysis of an organic nitrite and palladium with molecular oxygen as the sole clean oxidant. Linear α,β-unsaturated aldehydes could be efficiently prepared under aerobic catalytic conditions directly from the corresponding saturated linear aldehydes. Besides linear products, the aromatic analogy could also be smoothly achieved by the same standard method. The organic nitrite redox cocatalyst and alcohol solvent play a key role for realizing this method.

ANALGESIC 5, 9 - METHANOCYCLOOCTA (b) PYRIDIN - 2 (1H) - ONE DERIVATIVES, THEIR PREPARATION METHOD AND USE

Compounds represented by the Formula I or salts, hydrates thereof, wherein R1, R8, R11 and R12 are H or C1-4 hydrocarbonyl respectively; R2, R3, R6 and R7 are H, halogen or C1-4 hydrocarbonyl respectively; R4 is C1-6 hydrocarbonyl or Ar; or =CR4R3 is cyclopentylidene, cyclohexylidene, 1-methylpiperidyl-4-idene or indenyl-1-idene; R5 is H, 1-4 same or different F, Cl, Br, CF3, R9, OR9, NR9R10, NO2, CN, COOR9, O2CR9, CONR9R10, NR9C(O)R10, heterocyclic, aryl or groups represented by the Formula II respectively; R9 and R10 are H or C1-6 hydrocarbonyl; Ar is aromatic ring; m is 0, 1 or 2; n is 0, 1, 2, 3 or 4, for treating mammal pain, functional painful syndrome, organic painful syndrome or tissue painful syndrome, and their preparation method.

Reactions of Vinylphosphonates. 2. Synthesis of Functionalized Dienes, Trienes, and Their Analogues. Synthetic Aplications to Regioselectively Functionalized Benzene Derivatives

The phosphoryl-stabilized carboanions prepared from vinylphosphonates 1a,b and various carbanions 2a-c react with aldehydes 3 to give olefins having various functional groups.The dienes 5c-g produced by the reaction using α,β-unsaturated aldehydes and a methyl (methylsulfinyl)methyl sulfide carbanion (2b) easily undergo thermolysis to afford reactive intermediate 1-methylthio 1,3,5-trienes, which are converted into the 1,4-disubstituted benzenes 7a-e in 27-56percent overall isolated yields via the electrocyclic reaction into cyclohexadienes and subsequent elimination of methanethiol.Thermolysis of the reaction product using ethyl α-(diethylphosphono)acrylate (1a), 2b, and 1,4-bis(2-formylethenyl)benzene (3g) produces 4,4''-bis(ethoxycarbonyl)-1,1':4',1''-terphenyl (7f) in 16percent yield.The reaction using an ethyl (methylthio)acetate carbanion (2c) instead of 2b gives thermally stable dienes 5i-l in 38-52percent yields.Oxidation of the dienes 5i,k,l followed by thermolysis, leads to the 1,2,4-trisubstituted (8a,b) and 1,2-disubstituted benzenes (9).Similar treatment of the product 5m derived from 1a, 2c, and 3-phenylpropargylaldehyde (3f) produces a mixture of 2,4-bis(ethoxycarbonyl)biphenyl (8a) and ethyl 4-(ethoxycarbonyl)-7-phenylhepta-2,4-dien-6-ynoate (11) in 23percent and 32percent yields.