305365-98-4

Basic information

• Product Name: C₄₆H₅₁N₄O₁₇P
• Synonyms: C₄₆H₅₁N₄O₁₇P
• CAS NO: 305365-98-4
• Molecular Weight: 962.901
• Mol File: 305365-98-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₆H₅₁N₄O₁₇P(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₆H₅₁N₄O₁₇P(305365-98-4)
• EPA Substance Registry System: C₄₆H₅₁N₄O₁₇P(305365-98-4)

Safety Data

• Hazardous Substances Data: 305365-98-4(Hazardous Substances Data)

Upstream product

• 103285-22-9 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 
• 408512-17-4 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-(N,N,N',N'-tetraisopropyl)phosphorodiamidite 

Relevant articles and documents

Synthesis and properties of oligonucleotides having a phosphorus chiral center by incorporation of conformationally rigid 5'-cyclouridylic acid derivatives

This paper describes the design and synthesis of a conformationally rigid dimer building block Umpc3Um as a chiral center at the phosphate group with the S/N junction where c3 refers to a propylene bridge linked between the uracil 5-position and 5'-phosphate group of pUre. The extensive H1 NMR analysis of Umpc3Um suggests that the 5'-upstream Um has predominantly a C2'-endo conformation and the pc3Um moiety exists almost exclusively in a C3'-endo conformation. The absolute configuration of the diastereomers Umpc3Um(fast) (8a) and Umpc3Um(slow) (8b) was determined by CD spectroscopy as well as computer simulations. The oligonucleotides U4[Umpc3Um-(fast)]U4 (13a) and U4[Umpc3Um(slow)]U4 (13b) incorporating 8a and 8b were synthesized by use of the phosphoramidite building blocks 11a and 11b, respectively. The T(m) experiments of the duplexes formed between these modified oligomers and the complementary oligomers imply that the modified oligomer 13a having Umpc3Um(fast) has the Sp configuration at the chiral phosphoryl group.