305366-00-1

Upstream product

• 408512-17-4 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyluridine 3'-(N,N,N',N'-tetraisopropyl)phosphorodiamidite 
• 287101-03-5 3'-O-acetyl-5-(2-hydroxypropynyl)-2'-O-methyluridine 
• 287101-04-6 3'-O-acetyl-5-(2-hydroxypropyl)-2'-O-methyluridine 
• 287101-02-4 3'-O-acetyl-5-iodo-2'-O-methyluridine 
• 2140-76-3 2'-O-methyluridine 

Relevant academic research and scientific papers

Synthesis of artificially bent oligonucleotides by incorporation of conformationally rigid 5'-cyclouridylic acid derivatives

This paper describes the design and synthesis of a conformationally rigid dimer building block Umpc3Um having a propylene bridge linked between the uracil 5-position and 5'-phosphate group of pUm. Oligonucleotides incorporating the dimer unit with either the Sp or Rp configuration were synthesized by use of the phosphoramidite approach. The conformational properties of the dimer units and these oligonucleotides were studied in detail.