Synthesis of artificially bent oligonucleotides by incorporation of conformationally rigid 5'-cyclouridylic acid derivatives

Article abstract of DOI:10.1080/07328319908044653

This paper describes the design and synthesis of a conformationally rigid dimer building block Umpc3Um having a propylene bridge linked between the uracil 5-position and 5'-phosphate group of pUm. Oligonucleotides incorporating the dimer unit with either the Sp or Rp configuration were synthesized by use of the phosphoramidite approach. The conformational properties of the dimer units and these oligonucleotides were studied in detail.

Full text of DOI:10.1080/07328319908044653

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Nucleosides and Nucleotides
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Synthesis of Artificially Bent
Oligonucleotides by Incorporation of
Conformationally Rigid 5′-Cyclouridylic
Acid Derivatives
Mitsuo Sekine a , Osamu Kurasawa a , Kohji Seio a , Koh-Ichiroh
Shohda a & Takeshi Wada a
a Department of Life Science , Tokyo Institute of Technology ,
Nagatsuta, Midoriku, Yokohama, 226-8501, Japan
Published online: 04 Oct 2006.
To cite this article: Mitsuo Sekine , Osamu Kurasawa , Kohji Seio , Koh-Ichiroh Shohda & Takeshi
Wada (1999) Synthesis of Artificially Bent Oligonucleotides by Incorporation of Conformationally
Rigid 5′-Cyclouridylic Acid Derivatives, Nucleosides and Nucleotides, 18:6-7, 1163-1168, DOI:
10.1080/07328319908044653
To link to this article: http://dx.doi.org/10.1080/07328319908044653
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